Figure 1 | British Journal of Cancer

Figure 1

From: Microvascular density and hypoxia-inducible factor pathway in pancreatic endocrine tumours: negative correlation of microvascular density and VEGF expression with tumour progression

Figure 1

Immunohistochemical expression of VEGF, HIF-1α and HIF-2α by WHO-stage 1 (A, C, E and F) and WHO-stage 4 (B, D) PETs. (A, B) VEGF is highly expressed in a WHO stage-1 PET (A) and negative in a WHO-stage 4 PET (B). (C, D) HIF-1α cytoplasmic expression is strong in a WHO-stage 1 PET (C). HIF-1α nuclear expression is detected in a WHO-stage 4 PET (D). (E, F) HIF-2α cytoplasmic (E) and stromal (F) expression is detected in a WHO-stage 1 PET. Immunoperoxidase and haematoxylin nuclear counterstaining; original magnifications: A, × 250; B, × 250; C, × 150; D, × 500; E, × 200; F, × 250.

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