Figure 5 | British Journal of Cancer

Figure 5

From: Microvascular density and hypoxia-inducible factor pathway in pancreatic endocrine tumours: negative correlation of microvascular density and VEGF expression with tumour progression

Figure 5

Immunohistochemical expression of CA9 and CD34 by WHO-stage 1 (A, B) and WHO-stage 4 (C, D) pancreatic endocrine tumours and by VHL cases (E, F). (A, C, E) CA9 is not detected in most well-differentiated PETs (A). Its expression is strong and membranous around areas of necrosis in WHO-stage 4 PETs (C) and cytoplasmic diffuse in VHL cases (E). (B, D, F) CD34+ capillaries are numerous in WHO-stage 1 PETs (B) and scattered in WHO-stage 4 PETs (D). Microvascular density is very high in VHL cases (F). Immunoperoxidase and haematoxylin nuclear counterstaining; original magnifications: A, × 150; B, × 250; C, × 200; D, × 150; E, × 200; F, × 250.

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