Table 2 Cytoplasmic and nuclear expression of VEGF, HIF-1α, HIF-2α, CA9 and values of microvessel density according to VHL status in well-differentiated tumours (n=37)

From: Microvascular density and hypoxia-inducible factor pathway in pancreatic endocrine tumours: negative correlation of microvascular density and VEGF expression with tumour progression

  

VHL+ ( n =8)

VHL− ( n =29)

P

VEGF

Mean cytoplasmic score±s.d.

60±55

66±64

NS

HIF-1α

Mean cytoplasmic score±s.d.

95±70

215±83

0.03

 

Mean nuclear %±s.d.

12±9.4

6.3±7.7

0.04

HIF-2α

Mean cytoplasmic score±s.d.

10±20

14±28

NS

 

Mean nuclear %±s.d.

1.4±1.8

2±5.5

NS

CA9

Mean cytoplasmic score±s.d.

73±50

2.7±14.6

0.0001

CD34

Microvessel density (vessels mm−2)

563±189

215±82

0.02

  1. VHL+: von Hippel-Lindau disease cases; VHL−: cases without von Hippel-Lindau disease; s.d.: standard deviation; NS: nonsignificant.
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