Table 3 Association of PDGFRA expression with clinicopathological characteristics
From: Genetic alterations and protein expression of KIT and PDGFRA in serous ovarian carcinoma
PDGFRA immunohistochemical score | |||||||
|---|---|---|---|---|---|---|---|
Clinicopathological characteristics | Weak | % | Moderate | % | Strong | % | P-value |
FIGO stage | |||||||
 I | 12/58 | 21 | 83/380 | 22 | 9/64 | 14 | 0.0483 |
 II | 12/58 | 21 | 44/380 | 12 | 10/64 | 16 | |
 III | 23/58 | 40 | 208/380 | 55 | 41/64 | 64 | |
 IV | 11/58 | 19 | 45/380 | 12 | 4/64 | 6 | |
Grade | |||||||
 1 | 22/59 | 37 | 153/375 | 41 | 13/63 | 21 | 0.0019 |
 2 | 11/59 | 19 | 103/375 | 27 | 15/63 | 24 | |
 3 | 26/59 | 44 | 119/375 | 32 | 35/63 | 56 | |
Residual tumour | |||||||
 ⩽1 cm | 24/49 | 49 | 178/345 | 51 | 20/60 | 33 | 0.0330 |
 >1 cm | 25/49 | 51 | 167/345 | 49 | 40/60 | 67 | |
Age | |||||||
 <57 years | 29/59 | 49 | 185/382 | 48 | 31/64 | 48 | NS; 0.99 |
 ⩾57 years | 30/59 | 51 | 197/382 | 52 | 33/64 | 52 | |
Tumour size | |||||||
 ⩽10 cm | 26/58 | 45 | 122/377 | 32 | 23/61 | 38 | NS; 0.15 |
 >10 cm | 32/58 | 55 | 255/377 | 68 | 38/61 | 62 | |
Ascites | |||||||
 No | 26/56 | 46 | 130/377 | 34 | 22/63 | 35 | NS; 0.22 |
 Yes | 30/56 | 54 | 247/377 | 66 | 41/63 | 65 | |
Ki-67 | |||||||
 0–10% | 39/57 | 68 | 200/375 | 53 | 24/62 | 39 | 0.0060 |
 10–25% | 9/57 | 16 | 105/375 | 28 | 17/62 | 27 | |
 >25% | 9/57 | 16 | 70/375 | 19 | 21/62 | 34 | |
p53 | |||||||
 Normal | 27/58 | 47 | 155/372 | 42 | 17/63 | 27 | NS; 0.053 |
 Aberrant | 31/58 | 53 | 217/372 | 58 | 46/63 | 73 | |