Table 3 Event pathways
1. Family history questionnaire not returned |
2. Inappropriate referral |
3. Moderate risk – breast cancer |
4. Moderate risk – colorectal cancer |
5. Moderate risk – ovarian or breast ovarian cancer |
High risk – colorectal (HNPCC) |
6. Test cancer-affected relative (mutation found) and test presymptomatic patient |
7. Test cancer-affected relative (no mutation found) and do not test presymptomatic patient |
8. Test subsequent presymptomatic members of a family with an established mutation |
9. Counsel and arrange presymptomatic care for members of a family with no established mutation |
High risk – colorectal (FAP) |
10. Test cancer-affected relative (mutation found) and test presymptomatic patient |
11. Test cancer-affected relative (no mutation found) and do not test presymptomatic patient |
12. Test subsequent presymptomatic members of a family with an established mutation (using linkage testing) |
13. Test subsequent presymptomatic members of a family with an established mutation (using sequence analysis) |
14. Counsel and arrange presymptomatic care for members of a family with no established mutation |
High risk – breast (BRCA1/2) |
15. Test cancer-affected relative (mutation found) and test presymptomatic patient |
16. Test cancer-affected relative (no mutation found) and do not test presymptomatic patient |
17. Test subsequent presymptomatic members of a family with an established mutation |
18. Counsel and arrange presymptomatic care for members of a family with no established mutation |
High risk – ovarian or breast ovarian (BRCA1/2) |
19. Test cancer-affected relative (mutation found) and test presymptomatic patient |
20. Test cancer-affected relative (no mutation found) and do not test presymptomatic patient |
21. Test subsequent presymptomatic members of a family with an established mutation |
22. Counsel and arrange presymptomatic care for members of a family with no established mutation |
