Table 4 Toxicity by treatment cycle
Cycle | 1 (n=41) | 2 (n=40) | 3 (n=36) | 4 (n=30) | 5 (n=27) | 6 (n=20) | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Grade | 1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 |
Anaemia | 6 | 1 | 0 | 0 | 11 | 1 | 1 | 0 | 7 | 2 | 1 | 0 | 12 | 3 | 0 | 0 | 7 | 6 | 1 | 0 | 9 | 2 | 1 | 0 |
Neutropenia | 2 | 1 | 0 | 1 | 2 | 0 | 2 | 1 | 4 | 1 | 1 | 0 | 2 | 2 | 0 | 0 | 2 | 1 | 1 | 0 | 3 | 0 | 0 | 0 |
Thrombopenia | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 2 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Asthenia | 16 | 8 | 0 | 0 | 18 | 9 | 1 | 0 | 18 | 8 | 1 | 0 | 15 | 8 | 1 | 0 | 14 | 8 | 2 | 0 | 10 | 8 | 0 | 0 |
Anorexia | 8 | 3 | 0 | 0 | 11 | 8 | 0 | 0 | 16 | 6 | 1 | 0 | 11 | 7 | 1 | 0 | 14 | 8 | 2 | 0 | 11 | 6 | 0 | 0 |
Hand–foot | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 8 | 2 | 0 | 0 | 16 | 3 | 1 | 0 | 8 | 10 | 1 | 0 | 6 | 11 | 0 | 0 |
Constipation | 11 | 2 | 0 | 0 | 12 | 4 | 0 | 0 | 9 | 3 | 0 | 0 | 12 | 1 | 0 | 0 | 11 | 2 | 0 | 0 | 6 | 3 | 0 | 0 |
Nausea/vomiting | 6 | 1 | 0 | 0 | 5 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 2 | 3 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Alopecia | 0 | 0 | — | — | 2 | 0 | — | — | 9 | 0 | — | — | 8 | 0 | — | — | 8 | 1 | — | — | 7 | 0 | — | — |
Mucositis | 3 | 1 | 2 | 0 | 2 | 2 | 1 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Neuropathy | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 0 | 0 |
Diarrhoea | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cardiotoxicity | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
