Table 2 Incidence of DLTs during dose escalation
No. of patients | |||||
|---|---|---|---|---|---|
Dose level | Capecitabine (mg m −2 twice daily) | Irinotecan (mg m−2) | Treated | With DLT | DLTs |
1 | 700 | 200 | 4 | 0 | |
2 | 850 | 200 | 3 | 0 | |
3 | 1000 | 200 | 4 | 0 | |
4 | 1000 | 250 | 10 | 1 | Grade 3 diarrhoea, Grade 4 neutropenia/septicaemia |
5 | 1150 | 250 | 6 | 3 | Grade 3 diarrhoea/abdominal pain |
Grade 3 diarrhoea/Grade 4 neutropenia | |||||
Grade 4 diarrhoea/Grade 3 vomiting | |||||
