Table 3 Grade 3/4 treatment-related adverse events
Adverse events: Grade 3/Grade 4 | |||||
|---|---|---|---|---|---|
Dose level | 1 (n=4) | 2 (n=3) | 3 (n=4) | 4 (n=10) | 5 (n=6) |
Capecitabine (mg m−2 twice daily) | 700 | 850 | 1000 | 1000 | 1150 |
Irinotecan (mg m−2) | 200 | 200 | 200 | 250 | 250 |
Nausea | 1/0 | 0/0 | 1/0 | 0/1 | 2/0 |
Diarrhoea | 1/0 | 0/0 | 1/0 | 2/0 | 1/2 |
Vomiting | 1/0 | 0/0 | 0/0 | 0/1 | 2/0 |
Stomatitis | 0/0 | 0/0 | 0/0 | 0/0 | 1/0 |
Asthenia | 1/0 | 0/0 | 1/0 | 0/0 | 0/0 |
Abdominal pain | 0/0 | 0/0 | 0/0 | 0/0 | 1/0 |
Hand–foot syndrome | 0/0 | 0/0 | 1/0 | 0/0 | 0/0 |
Leucopenia | 1/0 | 0/0 | 0/0 | 1/0 | 1/0 |
Lymphopenia | 0/0 | 0/0 | 0/0 | 0/0 | 2/0 |
Neutropenia | 2/0 | 0/0 | 0/0 | 1/1 | 0/1 |
