Table 5 Mean AUC values for capecitabine, 5-FU and its metabolites
AUC (0–12 h) (s.d.) (mg ml −1 h) | ||||||||
|---|---|---|---|---|---|---|---|---|
Capecitabine | 5-FU | 5′-DFCR | 5′-DFUR | |||||
Capecitabine twice daily dose (mg m−2) | Cycle 1 | Cycle 2 | Cycle 1 | Cycle 2 | Cycle 1 | Cycle 2 | Cycle 1 | Cycle 2 |
700 | 3652 (1234) | 3208 (820) | 555 (157) | 322 (130) | 1929 N/A | 2087 (910) | 13 495 (4335) | 11 179 (1300) |
850 | 4343 (793) | 4248 (1156) | 407 (70) | 465 (210) | 1286 (586) | 1890 (1164) | 11 916 (1518) | 10 887 (1914) |
1000 | 7700 (3046) | 7322 (3620) | 478 (172) | 598 (326) | 6149 (3818) | 7285 (3610) | 14 341 (6769) | 15 836 (3048) |
1150 | 11 553 (5814) | 11 188 (7377) | 621 (156) | 516 (189) | 9967 (3526) | 11 110 (2520) | 18 001 (2572) | 16 289 (5383) |
