Table 2 Multivariate analysis (Cox) of recurrence rate ratio and breast cancer mortality rate ratio for oestrogen receptor (ER)-positive patients in relation to 17β-hydroxysteroid dehydrogenase (17HSD) types 1 and 2 and other variables

From: 17β-Hydroxysteroid dehydrogenases involved in local oestrogen synthesis have prognostic significance in breast cancer

 

Recurrence

Breast cancer mortality

 

RR (95% CI)

Significance

RR (95% CI)

Significance

HSD2/HSD1

 ⩽0.2

1.0

 

1.0

 

 >0.2

0.43 (0.23–0.80)

P=0.0083

0.43 (0.22–0.85)

P=0.015

Nodal status

 N−

1.0

 

1.0

 

 N+

2.2 (1.09–4.3)

P=0.027

2.6 (1.2–5.5)

P=0.012

Tumour size (mm)

 ⩽20

1.0

 

1.0

 

 >20

1.5 (0.83–2.7)

P=0.18

2.1 (1.08–4.2)

P=0.030

PgR status

 PgR−

1.0

 

1.0

 

 PgR+

0.72 (0.42–1.2)

P=0.24

0.73 (0.41–1.3)

P=0.30

Tamoxifen

 2 years

1.0

 

1.0

 

 5 years

0.75 (0.45–1.25)

P=0.27

0.99 (0.57–1.7)

P=0.98

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