Figure 1 | British Journal of Cancer

Figure 1

From: Insulin-like growth factor-1 (IGF1) genotype predicts breast volume after pregnancy and hormonal contraception and is associated with circulating IGF-1 levels: implications for risk of early-onset breast cancer in young women from hereditary breast cancer families

Figure 1

The figure shows the proposed mechanisms by which we hypothesise that absence of the IGF1 19-repeat allele in combination with hormone exposure would increase the breast volume and the risk of early-onset breast cancer. References to the steps that have been previously explored are indicted. The risk of early-onset breast cancer after hormone exposure may be partially modified through the IGF-1 pathway.

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