Figure 3

(A, B) show that the IGF1 genotype modified the effect of hormonal contraceptives on the IGF-1 levels in nulliparous women. The interaction between IGF-1 genotype and hormonal contraception was nonsignificant during cycle days 5–10 (P=0.13) and significant during cycle days 18–23, that is, 5–10 days prior to the predicted onset of the next menstrual period (P=0.026). The horizontal line in the box indicates the median value, the box boundaries the 25th and 75th percentiles, and the capped bars the 10th and the 90th percentiles. The number of women in each group is indicated. Circles indicate outliers with values between 1.5 and 3 box lengths from the upper or lower edge of the box. Asterisks indicate extreme outliers with values more than 3 box lengths from the upper or lower edge of the box. The box length is the interquartile range.