Table 1 Expression of VEGF, VEGFR1 and VEGFR2 on osteoclasts present in breast metastases to bone

From: Vascular endothelial growth factor acts as an osteolytic factor in breast cancer metastases to bone

Patient

Osteoclasts present

VEGF

VEGFR1

VEGFR2

1

+

++

++

++

2

+

++

++

++

3

−

−

−

−

4

+

++

++

++

5

+

++

+

++

6

+

+++

0

+

7

+

+++

+

++

8

+

++

0

++

9

−

−

−

−

10

+

++

+

++

11

+

++

++

++

12

+

++

++

+

13

+

+++

++

++

14

+

++

++

+++

15

+

++

++

++

16

−

−

−

−

17

+

++

++

++

  1. (−)=no osteoclasts present; (0)=negative staining; (+)=weak staining; (++)=moderate staining; (+++)=strong staining; VEGF=vascular endothelial growth factor; VEGFR1/2=vascular endothelial growth factor receptor 1/2.