Table 5 Correlation of oxaliplatin dose and dose intensity with outcomes (progression free survival and response rate) and toxicity

Regimen (ref.)	Regimen no.	PFS mos	Planned dose mg m ⁻²	Received dose intensity	Haematologic toxicity Grade 3/4 (%)	Neuro Tox. Grade 3 (%)	Resp. rate (%)
Folfox N=46 (Maindrault-Goebelt et al, 2000)	2	7	100	0.98	39	33	46^*
Folfox N=40 (Maindrault-Goebelt et al, 2000)	3	6	85	0.79	15	28	20^*
Folfox N=57 (Andre et al, 2003)	4	5.1	85	0.89	37	16	24^*
Folfox N=210 (De Gramont et al, 2000)	4	9.0	85	0.86	42	18	49^*
Folfox N=60 (Maindrault-Goebelt et al, 2000)	6	5.3	100	0.86	24	16	27^*
Folfox N=111 (Tournigand et al, 2004)	6	8.0	100	0.85	44	34	54^*
Folfox N=48 (Maindrault-Goebelt et al, 2000)	7		130	0.85	9	27	42^*
Cheeseman N=25 (Cheeseman et al, 2002)		10.6	85	NS	4	0^†	72^*
Goldstein N=61		8.2	100	0.83	36	21	51^*

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