Figure 6 | British Journal of Cancer

Figure 6

From: Targeting of Rad51-dependent homologous recombination: implications for the radiation sensitivity of human lung cancer cell lines

Figure 6

Rejoining of DNA-DSB in NSCLC cell lines treated with As-ODN. Constant-field gel electrophoresis showing the rejoining of IR-induced DNA-DSB in A549 cells after transfection with As-ODN (A). The fractions of DNA released into the gel as a measure for DNA Dsb at 0, 1 and 4 h after transfection and irradiation with 30 Gy are shown for A549 and H460 (B). Sham-irradiated controls (C) and irradiated cells previously transfected with lipofectamin only (L), UR ODN and As-ODN targeting Rad51 (As-rad51). Cells were treated with 20 μ M wortmannin (W20) or DMSO (W0) 1 h prior to irradiation with 30 Gy.

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