Table 2 Toxicity of the vinorelbine–HDFL regimen

From: Phase II study of weekly vinorelbine and 24-h infusion of high-dose 5-fluorouracil plus leucovorin as first-line treatment of advanced breast cancer

Toxicity

Patients ( n =40)

Cycles ( n =316)

Grade 1–2

Grade 3–4

Grade 1–2

Grade 3–4

Haematological

 Neutropenia

17.5%

80.0%

37.7%

38.0%

 Leucopenia

47.5%

40.0%

48.2%

18.0%

 Thrombocytopenia

10.0%

0

2.5%

0

 Febrile neutropenia

—

2.5%

—

0.3%

Gastrointestinal

 Nausea

80.0%

5.0%

49.4%

1.6%

 Vomiting

47.5%

10.0%

18.4%

2.2%

 Diarrhoea

35.0%

2.5%

8.2%

0.3%

 Stomatitis

55.0%

0

18.7%

0

Neuropathy

7.5%

0

3.8%

0

Hepatic

67.5%

2.5%

28.8%

0.3%

Others

 Hand–foot syndrome

57.5%a

5.0%b

NA

NA

 Infection

5.0%

0

1.6%

0

 Alopecia

75.0%

2.5%

54.7%

0.6%

  1. aGrade 1.
  2. bGrade 2–3.
  3. NA=nonapplicable by cycles.
Back to article page