Table 2 Pharmacokinetic parameters for radiolabelled ch806 in serum and tumour (mean±s.e.)

From: Engineering and characterisation of chimeric monoclonal antibody 806 (ch806) for targeted immunotherapy of tumours expressing de2-7 EGFR or amplified EGFR

 

T 1/2α (h)

T 1/2β (hr)

AUC (h  μ g ml−1)

CL (ml h−1)

Serum 111In-ch806

3.42±0.92

78.64±15.40

66.79±7.94

0.045±0.005

Serum 125I-ch806

2.85±0.24

69.87±6.56

47.52±2.61

0.063±0.003

Back to article page