Figure 3

Representative immunohistochemical staining for claudin-4 on two paraffin-embedded USPC specimens (B–C) and one NEC specimen (A). Normal endometrial cell 1 (upper panel) showed light membrane staining for claudin-4, while USPC 1 and USPC 3 showed heavy cytoplasmic and membranous staining for claudin-4 (middle and lower panel). Note the large difference in the size of USPC cells when compared to the control glandular epithelium of a menopausal women. Original magnification × 400.