Table 3 Upregulated genes expressed at least 10-fold higher in NEC compared with USPC

From: Gene expression fingerprint of uterine serous papillary carcinoma: identification of novel molecular markers for uterine serous cancer diagnosis and therapy

Probe set

Gene symbol

SAM

P of WRS

Ratio NEC/USPC

Title

774_g_at

MYH11

17.611

0.0027

1014.968759

‘Myosin, heavy polypeptide 11, smooth muscle’

773_at

MYH11

14.265

0.0027

968.0223497

‘Myosin, heavy polypeptide 11, smooth muscle’

32582_at

MYH11

11.277

0.0027

212.2458648

‘Myosin, heavy polypeptide 11, smooth muscle’

36681_at

APOD

11.714

0.0027

137.3140116

Apolipoprotein D

1501_at

IGF1

8.321

0.0027

128.0651104

Insulin-like growth factor 1 (somatomedin C)

39325_at

EBAF

8.177

0.0027

123.064609

‘Endometrial bleeding associated factor)’

767_at

—

12.707

0.0027

119.5409103

—

40398_s_at

MEOX2

10.182

0.0027

114.9489897

Mesenchyme homeo box 2

40776_at

DES

9.738

0.0027

109.416397

Desmin

1197_at

ACTG2

5.861

0.0027

96.65715109

‘Actin, gamma 2, smooth muscle, enteric’

36627_at

SPARCL1

7.724

0.0027

93.89302842

‘SPARC-like 1 (mast9, hevin)’

37407_s_at

MYH11

11.893

0.0027

88.70362054

‘Myosin, heavy polypeptide 11, smooth muscle’

39673_i_at

ECM2

8.459

0.0027

82.52353674

‘Extracellular matrix protein 2, female organ and adipocyte specific’

39701_at

PEG3

7.645

0.0027

73.87997223

Paternally expressed gene 3

39066_at

MFAP4

9.383

0.0027

68.84723295

Microfibrillar-associated protein 4

38737_at

IGF1

6.341

0.0027

65.13666715

Insulin-like growth factor 1 (somatomedin C)

35730_at

ADH1B

9.759

0.0027

64.94146631

‘Alcohol dehydrogenase IB (class I), beta polypeptide’

41124_r_at

ENPP2

7.007

0.0027

53.43118221

Ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin)

36749_at

CPA3

9.096

0.0027

53.07347991

Carboxypeptidase A3 (mast cell)

39616_at

PTGER3

10.188

0.0027

52.65326101

Prostaglandin E receptor 3 (subtype EP3)

33440_at

TCF8

7.220

0.0027

49.54168001

Transcription factor 8

32666_at

CXCL12

7.168

0.0027

49.2359637

Chemokine (C–X–C motif) ligand 12

38734_at

PLN

9.182

0.0027

47.86730799

Phospholamban

34203_at

CNN1

5.051

0.0027

47.0209722

‘Calponin 1, basic, smooth muscle’

37576_at

PCP4

12.468

0.0027

45.45542357

Purkinje cell protein 4

36834_at

MOXD1

9.736

0.0027

44.20917891

‘Monooxygenase, DBH-like 1’

37247_at

TCF21

9.810

0.0027

42.40051895

Transcription factor 21

37701_at

RGS2

7.408

0.0027

42.29038464

‘Regulator of G-protein signalling 2, 24 kDa’

779_at

COL4A6

5.840

0.0027

41.96325597

‘Collagen, type IV, alpha 6’

37394_at

C7

9.835

0.0027

40.72326307

Complement component 7

36533_at

PTGIS

6.097

0.0027

39.10052985

Prostaglandin I2 (prostacyclin) synthase

32689_s_at

—

6.178

0.0027

36.96897988

—

32905_s_at

TPSB2

6.873

0.0027

36.85974711

Tryptase beta 2

33240_at

SEMACAP3

4.814

0.0027

36.54583796

Likely ortholog of mouse semaF cytoplasmic domain associated protein 3

1466_s_at

FGF7

8.628

0.0027

35.60413415

Fibroblast growth factor 7

32686_at

PTGER3

7.397

0.0027

35.31357002

Prostaglandin E receptor 3 (subtype EP3)

39690_at

ALP

6.951

0.0027

33.76045029

Alpha-actinin-2-associated LIM protein

38427_at

COL15A1

7.196

0.0027

32.85391153

‘Collagen, type XV, alpha 1’

39939_at

COL4A6

6.846

0.0027

32.53815505

‘Collagen, type IV, alpha 6’

37630_at

NRLN1

5.896

0.0027

31.03030255

Neuralin 1

35717_at

ABCA8

7.587

0.0027

30.63819827

‘ATP-binding cassette, subfamily A, member 8’

1709_g_at

MAPK10

6.522

0.0027

30.54331363

Mitogen-activated protein kinase 10

35679_s_at

DPP6

5.899

0.0027

30.33959319

Dipeptidylpeptidase 6

35740_at

EMILIN1

7.445

0.0027

29.45261895

Elastin microfibril interfacer 1

41123_s_at

ENPP2

6.597

0.0027

29.29614059

Ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin)

755_at

ITPR1

8.211

0.0027

29.02124207

‘Inositol 1,4,5-triphosphate receptor, type 1’

32847_at

MYLK

5.388

0.0027

28.22518538

‘Myosin, light polypeptide kinase’

38001_at

CACNA1C

5.740

0.0027

27.31347302

‘Calcium channel, alpha 1C subunit’

37279_at

GEM

9.925

0.0027

26.56613192

GTP-binding protein overexpressed in skeletal muscle

36396_at

—

5.901

0.0027

26.32457357

Homo sapiens mRNA; cDNA DKFZp586N2020 (from clone DKFZp586N2020)

41137_at

PPP1R12B

12.043

0.0027

25.97089935

‘Protein phosphatase 1, regulatory subunit 12B’

41405_at

SFRP4

10.077

0.0027

23.90433923

Secreted frizzled-related protein 4

40775_at

ITM2A

6.152

0.0027

23.83083993

Integral membrane protein 2A

38059_g_at

DPT

6.508

0.0027

23.76376781

Dermatopontin

41504_s_at

MAF

5.331

0.0027

23.65323618

v-maf

1596_g_at

TEK

4.542

0.0027

23.37422615

‘TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)’

914_g_at

ERG

6.105

0.0027

22.63829292

v-ets erythroblastosis virus E26 oncogene like

34283_at

—

5.390

0.0041

22.19917455

‘Homo sapiens, clone IMAGE:4791553, mRNA’

34388_at

COL14A1

9.452

0.0027

21.48165459

‘Collagen, type XIV, alpha 1 (undulin)’

38994_at

SOCS2

6.600

0.0027

21.47663968

Suppressor of cytokine signaling 2

36065_at

LDB2

5.790

0.0027

21.19321308

LIM domain binding 2

40230_at

FRZB

5.962

0.0027

21.00467856

Frizzled-related protein

33790_at

CCL15

9.017

0.0027

20.5510028

Chemokine (C–C motif) ligand 15

33890_at

RGS5

7.347

0.0027

20.2203337

Regulator of G-protein signalling 5

36513_at

MAGP2

4.385

0.0041

20.10734871

Microfibril-associated glycoprotein-2

32526_at

JAM3

6.129

0.0027

19.89641568

Junctional adhesion molecule 3

32687_s_at

PTGER3

5.902

0.0027

19.7194642

Prostaglandin E receptor 3 (subtype EP3)

35638_at

CBFA2T1

10.470

0.0027

19.57233853

‘Core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related’

34637_f_at

ADH1A

6.291

0.0027

19.20847669

‘Alcohol dehydrogenase 1A (class I)’

34675_at

SBLF

5.400

0.0027

19.04463285

Stoned B-like factor

38351_at

—

5.899

0.0026

18.69131208

Homo sapiens mRNA; cDNA DKFZp586L0120 (from clone DKFZp586L0120)

1182_at

PLCL1

4.047

0.0027

18.50958764

Phospholipase C-like 1

39681_at

ZNF145

6.266

0.0027

18.41823634

‘Zinc-finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia)’

1708_at

MAPK10

6.336

0.0027

18.31250756

Mitogen-activated protein kinase 10

37765_at

LMOD1

7.586

0.0027

18.11624265

Leiomodin 1 (smooth muscle)

1678_g_at

IGFBP5

4.237

0.0041

17.88349387

Insulin-like growth factor binding protein 5

35358_at

TENC1

9.243

0.0027

17.68277053

Tensin-like C1 domain-containing phosphatase

33442_at

KIAA0367

6.830

0.0027

17.58195512

KIAA0367 protein

37249_at

PDE8B

5.035

0.0027

17.25176904

Phosphodiesterase 8B

33834_at

CXCL12

7.736

0.0027

17.10893345

Chemokine (C–X–C motif) ligand 12 (stromal cell-derived factor 1)

35324_at

SLIT3

5.157

0.0027

17.08441711

Slit homolog 3 (Drosophila)

37015_at

ALDH1A1

4.941

0.0027

16.83181709

‘Aldehyde dehydrogenase 1 family, member A1’

39266_at

—

6.237

0.0027

16.80733058

Homo sapiens clone 24405 mRNA sequence

33462_at

GPR105

4.907

0.0027

16.49634139

G protein-coupled receptor 105

32488_at

COL3A1

3.928

0.0027

16.44993439

‘Collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant)’

483_g_at

CDH13

3.755

0.0027

16.43857351

‘Cadherin 13, H-cadherin (heart)’

38026_at

FBLN1

5.350

0.0027

16.06497318

Fibulin 1

1909_at

BCL2

7.356

0.0027

16.01160367

B-cell CLL/lymphoma 2

36245_at

HTR2B

4.698

0.0027

15.77119379

5-Hydroxytryptamine (serotonin) receptor 2B

32057_at

LRRC17

5.470

0.0027

15.6891271

Leucine-rich repeat containing 17

39544_at

DMN

5.361

0.0027

15.66465434

Desmuslin

37112_at

C6orf32

4.720

0.0027

15.65975413

Chromosome 6 open reading frame 32

36733_at

FLJ32389

4.442

0.0027

15.64273348

Hypothetical protein FLJ32389

1319_at

DDR2

5.400

0.0027

15.5817123

‘Discoidin domain receptor family, member 2’

38057_at

DPT

8.479

0.0027

15.51358362

Dermatopontin

40358_at

GLI3

6.650

0.0027

15.11249492

GLI-Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome)

38627_at

HLF

4.947

0.0027

14.89249894

Hepatic leukemia factor

1731_at

PDGFRA

7.050

0.0027

14.84422948

‘Platelet-derived growth factor receptor, alpha polypeptide’

31897_at

DOC1

4.664

0.0027

14.80084961

Downregulated in ovarian cancer 1

2073_s_at

CDH13

5.076

0.0027

14.79118507

‘Cadherin 13, H-cadherin (heart)’

38577_at

—

7.283

0.0027

14.78670234

‘Clone DT1P1B6 mRNA, CAG repeat region’

38004_at

CSPG4

6.072

0.0027

14.40637488

Chondroitin sulphate proteoglycan 4

32109_at

FXYD1

7.333

0.0027

14.33463902

Phospholemman

34853_at

FLRT2

9.834

0.0027

14.33080432

Fibronectin leucine-rich transmembrane protein 2

38298_at

KCNMB1

7.046

0.0027

14.25816751

‘Potassium large-conductance calcium-activated channel, subfamily M, beta member 1’

41245_at

GDF10

6.643

0.0027

14.21467179

Growth differentiation factor 10

38322_at

GAGEC1

6.215

0.0027

14.10508119

‘G antigen, family C, 1’

1198_at

EDNRB

4.899

0.0027

14.08196951

Endothelin receptor type B

41505_r_at

MAF

4.528

0.0027

14.0059518

v-maf

36976_at

CDH11

3.692

0.0027

14.00329993

‘Cadherin 11, type 2, OB-cadherin (osteoblast)’

32688_at

PTGER3

4.998

0.0027

13.68791213

Prostaglandin E receptor 3 (subtype EP3)

1575_at

ABCB1

6.210

0.0027

13.64196645

‘ATP-binding cassette, subfamily B’

32778_at

ITPR1

4.914

0.0027

13.60359986

‘Inositol 1,4,5-triphosphate receptor, type 1’

40737_at

KCNMA1

5.642

0.0027

13.60011778

‘potassium large-conductance calcium-activated channel, subfamily M, alpha member 1’

36569_at

TNA

11.512

0.0027

13.14186685

Tetranectin (plasminogen-binding protein)

1897_at

TGFBR3

4.922

0.0041

12.99722509

‘Transforming growth factor, beta receptor III (betaglycan, 300 kDa)’

2087_s_at

CDH11

4.345

0.0027

12.96131894

‘Cadherin 11, type 2, OB-cadherin (osteoblast)’

34820_at

PTN

4.413

0.0041

12.94626537

‘Pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)’

743_at

NAP1L3

7.859

0.0027

12.91061134

Nucleosome assembly protein 1-like 3

1507_s_at

EDNRA

4.319

0.0041

12.88466839

Endothelin receptor type A

38995_at

CLDN5

12.156

0.0027

12.86636376

Claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)

1147_at

—

7.084

0.0027

12.69931721

—

1954_at

KDR

6.077

0.0027

12.6174344

Kinase insert domain receptor (a type III receptor tyrosine kinase)

38786_at

—

5.676

0.0027

12.61170471

Homo sapiens mRNA full-length insert cDNA clone EUROIMAGE 248114

40757_at

GZMA

4.575

0.0041

12.56281091

‘Granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)’

36695_at

na

5.776

0.0027

12.53905775

Similar to hypothetical protein 6720478C22

32052_at

HBB

5.107

0.0063

12.52262761

‘Haemoglobin, beta’

37446_at

GASP

8.227

0.0027

12.39360585

G protein-coupled receptor-associated protein

38038_at

LUM

4.462

0.0027

12.34757673

Lumican

32889_at

RPIB9

6.337

0.0027

12.34540513

Rap2-binding protein 9

35234_at

RECK

4.476

0.0027

12.33793353

Reversion-inducing-cysteine-rich protein

661_at

GAS1

4.648

0.0027

12.32556384

Growth arrest-specific 1

41195_at

LPP

6.292

0.0027

12.26636801

LIM domain containing preferred translocation partner in lipoma

32664_at

RNASE4

6.395

0.0027

11.89680804

‘Ribonuclease, RNase A family, 4’

39038_at

FBLN5

4.325

0.0027

11.89440528

Fibulin 5

40693_at

KCNB1

4.952

0.0041

11.84773944

‘Potassium voltage-gated channel, Shab-related subfamily, member 1’

38052_at

F13A1

5.346

0.0027

11.69181717

‘Coagulation factor XIII, A1 polypeptide’

35220_at

ENPEP

4.200

0.0027

11.66308093

Glutamyl aminopeptidase (aminopeptidase A)

37512_at

RODH

5.112

0.0027

11.65031202

3-Hydroxysteroid epimerase

103_at

THBS4

5.114

0.0027

11.6063075

Thrombospondin 4

36156_at

AQP1

6.927

0.0027

11.6016663

‘Aquaporin 1’

39593_at

FGL2

5.176

0.0027

11.38223584

Fibrinogen-like 2

33248_at

HOXA11

6.555

0.0027

11.34828098

Homeo box A11

41420_at

IGFBP5

4.166

0.0041

11.32365037

Insulin-like growth factor binding protein 5

35644_at

HEPH

6.666

0.0027

11.26324425

Hephaestin

39646_at

CACNB2

4.719

0.0027

11.25017414

‘Calcium channel, voltage-dependent, beta 2 subunit’

35333_r_at

DVS27

4.403

0.0027

11.23759398

DVS27-related protein

33182_at

—

4.990

0.0027

11.20258783

Homo sapiens mRNA full-length insert cDNA clone EUROIMAGE 1630957

34303_at

FLJ90798

4.909

0.0027

11.10458088

Hypothetical protein FLJ90798

33756_at

AOC3

5.186

0.0027

11.09776026

‘Amine oxidase, copper containing 3 (vascular adhesion protein 1)’

37710_at

MEF2C

7.485

0.0027

11.03832245

‘MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C)’

35680_r_at

DPP6

3.783

0.0027

10.88151987

Dipeptidylpeptidase 6

40126_at

—

4.620

0.0027

10.87424764

—

31831_at

SMTN

5.712

0.0027

10.84917408

Smoothelin

234_s_at

PTN

5.660

0.0041

10.803161

‘Pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)’

36939_at

GPM6A

4.981

0.0027

10.76644676

Glycoprotein M6A

41158_at

PLP1

4.879

0.0027

10.76462278

‘Proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated)’

41839_at

GAS1

4.401

0.0027

10.75375673

Growth arrest-specific 1

1186_at

GDF10

4.165

0.0063

10.74677086

Growth differentiation factor 10

35404_at

TACR2

4.416

0.0063

10.67366905

Tachykinin receptor 2

160023_at

WNT2

5.424

0.0027

10.67077677

Wingless-type MMTV integration site family member 2

34561_at

MS4A2

6.380

0.0027

10.6336763

‘Membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)’

36280_at

GZMK

4.739

0.0027

10.5607572

‘Granzyme K’

35668_at

RAMP1

3.430

0.0027

10.4886967

Receptor (calcitonin) activity modifying protein 1

32521_at

SFRP1

4.488

0.0027

10.43051698

Secreted frizzled-related protein 1

1975_s_at

IGF1

7.381

0.0027

10.34307322

Insulin-like growth factor 1 (somatomedin C)

37671_at

LAMA4

5.094

0.0027

10.34084543

‘Laminin, alpha 4’

40013_at

CLIC2

5.388

0.0027

10.2736905

Chloride intracellular channel 2

32782_r_at

BPAG1

4.597

0.0027

10.2197061

‘Bullous pemphigoid antigen 1, 230/240 kDa’

36918_at

GUCY1A3

4.344

0.0027

10.18606373

‘Guanylate cyclase 1, soluble, alpha 3’

32239_at

MATN2

6.197

0.0027

10.14895891

Matrilin 2

36503_at

CCL21

6.812

0.0027

10.09354903

Chemokine (C–C motif) ligand 21

38508_s_at

TNXB

8.826

0.0027

10.0794719

Tenascin XB

35146_at

TGFB1I1

5.562

0.0027

10.0680837

Transforming growth factor beta 1

38653_at

PMP22

6.085

0.0027

10.04665889

Peripheral myelin protein 22

342_at

ENPP1

5.008

0.0041

10.0434301

Ectonucleotide pyrophosphatase/phosphodiesterase

32826_at

ENTPD1

6.423

0.0027

10.01186286

Ectonucleoside triphosphate diphosphohydrolase 1

40318_at

DNCI1

3.348

0.0063

10.00454416

‘Dynein, cytoplasmic, intermediate polypeptide 1’

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