Table 2 Clinical responses of patients

From: Immune responses to the 105AD7 human anti-idiotypic vaccine after intensive chemotherapy, for osteosarcoma

Trial number

Clinical risk group

Interval from last chemo to vaccination

Immune response group

No. of prior relapses

Disease at study entry

Subsequent course

Current status

FU a

(m)

Date of last FU info

3

1

24

I

0

NMD

Never relapsed

ADF

45

09/04/02

21

1

16

I

2

NMD

Never relapsed

ADF

34

11/11/2000

26

1

21

I

0

NMD

Never relapsed

ADF

28

27/12/2001

28

2

25

I

0

NMD

Never relapsed

ADF

24

03/02/2003

6

1

14

I

2

NMD

Nodal and bone relapse

DOD

18

18/10/2001

12

1

12

I

0

NMD

Two further relapses

DOD

26

17/10/2000

22

1

22

I

2

Equivocal PD in lungs on CT

PD lungs

DOD

18

04/12/2002

24

1

12

I

3

Macroscopic residue

Local recurrence and lung mets

DOD

4

25/11/2002

9

1

22

II

0

Residual inoperable primary & metastatic disease

No further progressions

ADF

49

06/10/2003

17

1

22

II

1

NMD

No further relapse

ADF

33

26/06/2003

23

2

25

II

0

NMD

Never relapsed

ADF

31

20/07/2001

20

1

21

II

2

NMD

PD lungs

AWD

34

17/10/2002

7

1

20

II

1

Local recurrence

Local PD

DOD

6

27/01/2003

16

2

14

II

0

NMD

Two further relapses (lung and abdo)

DOD

19

20/11/2002

31

1

12

II

2

NMD

One further relapse

DOD

8

02/10/2001

1

2

21

III

0

NMD

pulm mets during vaccination

ADF

61

26/10/2003

5

1

27

III

1

NMD

No further relapse

ADF

45

02/01/03

10

1

25

III

1

NMD

Two skin relapses in thoracotomy scar

ADF

32

17/02/2000

11

2

8

III

0

NMD

Never relapsed

ADF

44

01/01/2003

29

2

18

III

0

NMD

Never relapsed

ADF

26

12/09/2001

2

1

19

III

3

NMD

Relapsed, Feb 2002

AWD

50

20/06/2002

4

1

11

III

2

NMD

Further pulm relapse

DOD

10

26/06/2003

8

1

11

III

0

NMD

Three further relapses

DOD

25

13/11/2002

13

1

9

III

1

NMD

One further relapse

DOD

36

24/05/2001

14

1

7

III

1

NMD

Further pulm relapse

DOD

17

13/02/2000

15

1

22

III

4

PD

Continued PD

DOD

2

22/06/2001

18

1

9

III

1

NMD

Local recurrence, then mediastinal recurrence, further local recurrence

DOD

16

07/07/2001

27

1

23

III

2

NMD

Pulmonary relapse

DOD

7

04/02/2003

  1. NMD=no measurable disease; PD=progressive disease.
  2. aFU is months from study entry.
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