Table 1 Clinicopathological data and EZH2 mRNA expression in the tumour tissue specimens from 66 patients with HCC

From: Clinicopathological significance of EZH2 mRNA expression in patients with hepatocellular carcinoma

Variables

Low expression groupa (n =33)

High expression groupa (n =33)

P -value

Sex (male : female)

21 : 12

21 : 12

0.99

Age (years)

64.6±9.3

62.1±10.4

0.31

Liver function

 HbsAg (+) (%)

2.3 (4/33)

30.3 (10/33)

0.07

 HCV antibody (+) (%)

63.6 (21/33)

69.7 (23/33)

0.60

 Platelet count × 104 (ml−1)

95.5±15.9

75±12.2

0.31

 Prothrombin time (%)

91.9±3.5

87±14.3

0.28

 Albumin (g dl−1)

3.8±0.1

3.9±0.1

0.38

 Total bilirubin (mg dl−1)

0.9±0.1

0.9±0.1

0.85

 ALT (IU l−1)

53±7.1

55.6±6

0.79

 ICGR15 (%)

17.3±1.8

14.6±1.7

0.27

Tumour factors

 Tumour size (cm)

3.9±0.3

5.1±0.6

0.07

 fc (+) (%)

84.8 (28/33)

78.8 (26/33)

0.52

 fc-inf (+) (%)

65.6 (21/32)

71.9 (23/32)

0.59

 vp (+)(%)

39.3 (13/33)

78.8 (26/33)

< 0.001

 vv (+)(%)

6.1 (2/33)

9.1 (3/33)

0.59

 b(+) (%)

3.0 (1/33)

12.1 (4/33)

0.15

 im (+)(%)

36.4 (12/33)

42.4 (14/33)

0.61

 Well/moderately/poorlyb

5/22/6

1/21/11

0.12

Staging

 I (%)

18.2 (6/33)

0.1 (1/32)

0.22

 II (%)

27.3 (9/33)

37.5 (12/32)

 

 III (%)

30.0 (10/33)

33.3 (11/32)

 

 IV (%)

0.1 (8/33)

25 (8/32)

 
  1. HCC=hepatocellular carcinoma; HBsAg=hepatitis B surface antigen; HCV=hepatitis C virus; AST=aspartate transaminase; ICG R15=indocyanine green dye retention test at 15 min; fc=capsular formation; fc-inf=tumour invasion to fc; vp=invasion to portal vein; vv=invasion to hepatic vein; b=invasion to bile duct; im=intrahepatic metastasis.
  2. aThe low and high expression groups were determined by a median value of EZH2 mRNA in the 66 tumour tissue specimens.
  3. bHistologic differentiation of the tumour.
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