Table 2 Genes significantlya regulated by (a) both gastrin and HGF, (b) gastrin and not by HGF and (c) HGF and not by gastrin

From: Identification of novel growth factor-responsive genes in neuroendocrine gastrointestinal tumour cells

   

Ratio c

Gene symbol

Gene name

Accession b

Gastrin

HGF

(a) Both gastrin and HGF

 Cell proliferation

ATF4

Activating transcription factor 4

AA600217

1.63

1.46

CCNI

Cyclin I

AA434408

1.52

1.42

ANXA11

Annexin A11

AA465051

1.47

1.27

MCM3

Minichromosome maintenance deficient 3

AA455786

1.35

1.38

NP

Nucleoside phosphorylase

AA430382

1.29

1.30

STK12

Serine/threonine kinase 12

AA071486

1.25

1.28

IL2RB

Interleukin 2 receptor, beta

AA057156

0.48

0.46

GNRH1

Gonadotropin-releasing hormone 1

AA043996

0.55

0.57

EPS15

EGF receptor pathway substrate 15

AA490223

0.66

0.63

LOC51177

CK2-interacting protein 1

AA490216

0.76

0.75

SCYA16

Small inducible cytokine subfamily A (Cys–Cys), member 16

T58775

0.77

0.70

 Apoptosis

BAK1

BCL2 antagonist/killer 1

H52673

1.26

1.29

HCLS1

Hematopoietic cell-specific Lyn substrate 1

AA424575

0.77

0.77

 Cell adhesion/motility

LGALS3BP

Lectin, galactoside-binding, soluble, 3 binding protein

AA485353

1.54

1.45

MAP1B

Microtubule-associated protein 1B

AA219045

1.54

1.33

LAMR1

Laminin receptor 1

AA629897

1.49

1.41

MIG

Monokine induced by gamma interferon

AA131406

0.53

0.66

CCR1

Chemokine (C–C) motif receptor 1

AA036881

0.63

0.60

CDH11

Cadherin 11

AA136983

0.66

0.65

LAMA5

Laminin, alpha 5

AA459519

0.77

0.72

ITGAV

Integrin, alpha V

AA029934

0.77

0.78

 Oncogenesis

MLF2

Myeloid leukemia factor 2

AA480835

1.30

1.40

CIN85

c-Cbl-interacting protein

AA989257

1.31

1.26

LMO2

LIM domain only 2

AA464644

1.29

1.31

GSTT1

Gluatathione S-transferase theta 1

H99813

1.25

1.35

PIM1

Pim-1 oncogene

AA453663

0.75

0.50

RAB18

RAB18, member RAS oncogene family

AA156821

0.79

0.75

Gene symbol

Gene name

Accession b

Ratio c

 

(b) Gastrin and not by HGF

 Cell proliferation

RRM2

Ribonucleotide reductase M2 polypeptide

AA187351

1.59

 

BTG1

B-cell translocation gene 1

N70463

1.57

 

IL-8

Interleukin 8

AA102526

1.46

 

EGR3

Early growth response 3

R39111

1.45

 

ERCC5

Excision repair crosscomplementing rodent repair deficiency, complementation group 5

N62586

1.44

 

MCM3

Minichromosome maintenance deficient 3

AA455786

1.35

 

FGF1

Fibroblast growth factor 1 (acidic)

AA015793

1.30

 

ETR101

Immediate-early protein

AA496359

1.27

 

RAD23A

RAD23 (C. cervisiae) homolog A

AA476274

1.26

 

CAMK2D

Calcium/calmodulin-dependent protein kinase (camkinase) II delta

AA283023

1.26

 

LIG3

Ligase III, DNA, ATP dependent

AA149292

0.61

 

HDAC2

Histone deacetylase 2

AA127093

0.72

 

 Apoptosis

PPARG

Peroxisome proliferative-activated receptor, gamma

A088517

1.3

 

LTBR

Lymphotoxin beta receptor

AA454646

0.67

 

 Cell adhesion/motility

RCN2

Reticulocalbin 2

AA598676

1.36

 

SERPINA5

Serine (or cysteine) proteinase inhibitor, member 5

AA858026

1.28

 

CDH6

Cadherin 6

AA421819

1.25

 

SYK

Spleen tyrosine kinase

AA598572

0.63

 

IGFBP1

Insulin-like growth factor binding protein 1

AA233079

0.66

 

SCYA2

Small inducible cytokine A2

AA425102

0.71

 

MMP7

Matrix metalloproteinase 7

AA031513

0.78

 

 Oncogenesis

HOXA1

Homeo box A1

AA173290

1.33

 

S100A3

S100 calcium-binding protein A3

AA055242

1.29

 

EWSR1

Ewing sarcoma break point region 1

AA464184

1.29

 

UBE3A

Ubiquitin protein ligase E3A

N94099

1.29

 

SIAT4C

Sialyltransferase 4C

AA453898

1.25

 

CHC1L

Chromosome condensation 1-like

AA495766

0.66

 

LBC

Lymphoid blast crisis oncogene

AA156936

0.70

 

MEL

Mel transforming oncogene

AA064715

0.77

 

OS-9

Amplified in osteosarcoma

AA03336

0.77

 

(c) HGF and not by gastrin

 Cell proliferation

ELK4

ETS-domain protein (SRF accessory protein 1)

H61758

1.55

 

MAT2A

Methionine adenosyltransferase II, alpha

T59286

1.53

 

MAPK4

Mitogen-activated protein kinase 4

AA401035

1.40

 

IGF2R

Insulin-like growth factor 2 receptor

T62547

1.32

 

PDGFRA

PDGF receptor alpha polypeptide

H23235

1.27

 

CDC6

CDC6 homolog

H59203

1.26

 

GSK3B

Glycogen synthase kinase 3 beta

R93911

1.26

 

BDNF

Brain-derived neurotrophic factor

AA262988

0.66

 

TNFRSF11B

TNF receptor superfamily, member 11

AA194983

0.67

 

JUND

Jun D proto-oncogene

AA418670

0.73

 

TSC22

TGF beta-stim protein TSC-22

AA664389

0.75

 

STATI2

STAT induced STAT inhibitor 2

AA137031

0.78

 

TOB1

Transducer of ERBB2,1

AA490213

0.79

 

 Apoptosis

TIMP3

Tissue inhibitor of metalloproteinase 3

AA099153

0.55

 

BIRC1

Baculoviral IAP repeat-containing 1

AA621150

0.80

 

 Cell adhesion/motility

ACTG2

Actin, gamma 2, smooth muscle, enteric

T60048

1.52

 

COL1A2

Collagen, type I, alpha 2

AA490172

1.35

 

MYPT2

Myosin phosphatase, target subunit 2

AA463926

1.36

 

DSP

Desmoplakin (DPI, DPII)

H90899

1.30

 

PCDH1

Protocadherin 1 (cadherin-like 1)

AA443557

1.27

 

CD164

CD164 antigen, sialomucin

AA598561

0.55

 

SDC4

Syndecan-4

AA148736

0.72

 

CD58

CD58 antigen

AA136359

0.75

 

 Oncogenesis

WT1

Wilms tumor 1

AA130187

0.76

 

KIAA0203

KIAA0203 gene product

AA047435

0.76

 
  1. HGF=hepatocyte growth factor.
  2. Significantly (P⩽0.05) differentially expressed genes with a microarray ratio <0.8 or >1.25 using the two-step procedure outlined in the Materials and Methods section.
  3. bGenBank accession number. Listed are genes with functions relevant in cancer biology. The remaining genes with other or unknown functions are listed in Supplementary Data. The gastrin data are based on samples from two biological experiments, of which one sample was hybridised once, and the other twice. The HGF data are based on samples from two biological experiments, which both were hybridised twice.
  4. cMicroarray ratio (treated/untreated cells).
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