Table 3 Observed performance characteristics for lesions ⩾CIN3 for cytology, cytology+hrHPV and hrHPV testing

From: Long-term protective effect of high-risk human papillomavirus testing in population-based cervical screening

 

Sensitivity

Specificity

Positive predictive value

Negative predictive value

Cytology

64.3 (35.6–86.0)

95.1 (94.2–96.0)

7.3 (3.9–13.3)

99.78 (99.48–99.90)

Cytology+HrHPV

92.9 (64.2–99.6)**

92.7 (91.5–93.7)*

7.0 (4.2–11.7)†

99.95 (99.74–99.99)**

HrHPV

92.9 (64.2–99.6)**

96.7 (95.9–97.4)*

14.6 (8.7–23.4)**

99.96 (99.75–99.99)**

  1. Expected performance characteristics for cytology and a combined test, which assumes that the second test is random with the same prevalence as hrHPV (3.7%), with respect to disease detection: sensitivity 65.6 (36.8–86.9), specificity 91.6 (90.3–92.6), PPV 4.4 (2.4–8.2), NPV 99.78 (99.47–99.91); P-values for differences in performance characteristics compared to cytology:
  2. *P⩽0.05;
  3. **P⩽0.1;
  4. †P>0.1.
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