Table 2 ORs for breast cancer risk associated with alcohol intake stratified by ADH1B genotype

From: Alcohol dehydrogenase 1B (ADH1B) genotype, alcohol consumption and breast cancer risk by age 50 years in a German case–control study

 

ADH1B*1/*1 genotype

ADH1B*2 carrier

 

Cases/controls

OR a

95% CI

Cases/controls

OR a

95% CI

Alcohol consumption (g day on average−1)

 0

101/147

1 (Ref)

 

16/29

1 (Ref)

 

 1–5

200/407

0.74

0.54–1.01

33/47

0.81

0.34–1.91

 6–11

104/226

0.70

0.49–0.99

9/13

0.87

0.25–3.02

 12+

143/193

1.12

0.78–1.59

7/20

0.29

0.08–1.00

 P-value for trendb

 

0.03

  

0.04

 
  1. ADH1B=alcohol dehydrogenase 1B; OR=odds ratio; CI=confidence interval.
  2. aORs stratified for age by 5-year intervals; additional adjustment was made for first-degree family history (yes/no), parity (0, 1–2, 3+ children), menopausal status (pre-, postmenopausal, unknown), education (low, intermediate and high) and smoking status (never, former and current active smoking) as categorical variables and breastfeeding (total duration in months) as continuous variable;
  3. bTest for linear trend (mean of categories used).
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