Table 2 RRs of breast cancer by body silhouette at different ages. E3N study, 1990–2000

From: Body silhouette, menstrual function at adolescence and breast cancer risk in the E3N cohort study

Variables

Cases

Person-years

Crude RRs

Multivariate RRs a

Multivariate RRs b

Premenopausal women

 Silhouette at age 8

1

490

155 593

1.00 (reference)

1.00 (reference)

1.00 (reference)

2

173

68 759

0.85 (0.71–1.01)

0.84 (0.71–1.00)

0.88 (0.71–1.09)

3

124

44 808

0.93 (0.76–1.13)

0.91 (0.75–1.11)

0.95 (0.74–1.21)

4

60

26 709

0.75 (0.57–0.98)

0.73 (0.56–0.96)

0.69 (0.49–0.97)

⩾5

21

7813

0.84 (0.54–1.32)

0.84 (0.54–1.32)

0.82 (0.46–1.47)

P for trend*

  

<0.01

<0.01

<0.05

 Silhouette around menarche

1

171

60 763

1.00 (reference)

1.00 (reference)

1.00 (reference)

2

315

99 207

1.23 (1.03–1.47)

1.23 (1.03–1.47)

1.20 (0.97–1.50)

3

224

78 310

1.11 (0.92–1.34)

1.13 (0.93–1.37)

1.03 (0.82–1.31)

4

134

52 716

0.98 (0.79–1.21)

0.97 (0.77–1.20)

0.90 (0.68–1.19)

⩾5

40

17 908

0.86 (0.61–1.21)

0.86 (0.61–1.21)

0.79 (0.51–1.22)

P for trend*

  

<0.05

<0.05

<0.05

 Silhouette at age 20–25

1

66

28 313

1.00 (reference)

1.00 (reference)

1.00 (reference)

2

418

133 410

1.33 (1.06–1.66)

1.35 (1.07–1.70)

1.26 (0.94–1.68)

3

293

111 187

1.12 (0.89–1.41)

1.14 (0.90–1.45)

1.13 (0.84–1.52)

4

97

35 457

1.14 (0.86–1.51)

1.13 (0.84–1.51)

1.11 (0.77–1.60)

⩾5

22

9314

0.99 (0.62–1.56)

1.01 (0.63–1.61)

0.97 (0.54–1.76)

P for trend*

  

NS

NS

NS

Postmenopausal women

 Silhouette at age 8

1

1 357

349 402

1.00 (reference)

1.00 (reference)

1.00 (reference)

2

446

127 097

0.94 (0.85–1.05)

0.95 (0.85–1.05)

0.97 (0.85–1.10)

3

299

82 286

0.97 (0.86–1.10)

0.98 (0.86–1.11)

0.99 (0.85–1.15)

4

177

51 588

0.92 (0.79–1.08)

0.93 (0.79–1.09)

0.87 (0.72–1.07)

⩾5

49

16 973

0.77 (0.58–1.03)

0.76 (0.57–1.02)

0.69 (0.48–1.01)

P for trend*

  

<0.05

<0.05

<0.01

 Silhouette around menarche

1

598

148 043

1.00 (reference)

1.00 (reference)

1.00 (reference)

2

811

206 646

1.05 (0.96–1.16)

1.07 (0.97–1.18)

1.07 (0.95–1.21)

3

527

149 494

0.95 (0.85–1.06)

0.96 (0.86–1.08)

0.99 (0.86–1.14)

4

316

98 130

0.87 (0.77–1.00)

0.88 (0.77–1.01)

0.83 (0.70–0.98)

⩾5

120

35 545

0.91 (0.75–1.11)

0.91 (0.75–1.10)

0.84 (0.66–1.08)

P for trend*

  

<0.001

<0.001

<0.001

 Silhouette at age 20–25

1

296

72 926

1.00 (reference)

1.00 (reference)

1.00 (reference)

2

1 021

277 394

0.95 (0.84–1.06)

0.95 (0.84–1.07)

0.97 (0.84–1.13)

3

778

221 901

0.91 (0.80–1.02)

0.91 (0.80–1.04)

0.90 (0.75–1.03)

4

271

73 285

0.95 (0.81–1.11)

0.97 (0.82–1.13)

0.97 (0.79–1.17)

⩾5

80

21 625

0.95 (0.74–1.20)

0.94 (0.73–1.19)

0.93 (0.68–1.25)

P for trend*

  

NS

NS

NS

  1. RR=relative risk; FFTP=first full-term pregnancy; NS=nonsignificant.
  2. aAdjusted for menopause, age at menarche, age at FFTP, parity, marital status, number of years at school, height, alcohol consumption, familial history of breast cancer in first-degree relatives, personal history of benign breast disease, oral contraceptive use and physical activity.
  3. bAdditionally adjusted for BMI at baseline (1990), regularity of menstrual cycles when adult, interval between age at menarche and onset of regular cycling.
  4. *Performed on the continuous variable ranked from 1 to 5+.
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