Figure 1
From: Role of insulin-like growth factor 1 receptor signalling in cancer
Interplay between p53, MDM2 and IGF-1R. The upper part of scheme shows that MDM2 can decrease p53 synthesis but also associate (indicated by dotted arrows) to it. This causes ubiquitination of p53. On the right it is indicated that p19 ARF can associate (dotted arrow) to MDM2. This prevents MDM2 association to p53.
