Table 2 Distribution of melanoma-NST pedigrees by tumour type and family affiliation
Proband | Affected relatives | Unaffected relatives | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Family # | DNA# | MM (a) | NST (b) | Additional cancers | MM | NST (b) | Additional cancers | ||||
(n =24) | (n =25) | Gender | (Age at diagnosis) | (Age at diagnosis) | DNA# | Gender | Age | ||||
116 | 115 | F | 68 | 64 (c) | BCC (66) | — | Mother | Lung (uncle) | 139 | F | 35 |
SCC (69) | (47) (x) | ||||||||||
120 | 218 | M | 51 | 51 (c) | BCC | — | — | Pleura (father) | — | — | — |
219 | M | — | 16 (b) | brother | |||||||
122 | 221 | M | 51 | 51 (g) | — | — | Father (84) (x) | Colon (mother) | — | — | — |
110 | 5 | M | 52 | 45 (f) | — | Sister (50) | — | — | 4 | M | 15 |
2 | F | 20 | |||||||||
3 | M | 21 | |||||||||
105 | 88 | F | 58 | 68 (c) | — | — | — | — | — | — | — |
67 | |||||||||||
113 | 165 | M | 57 | 19 (x) | BCC | — | — | Lung (mother) | 194 | M | 65 |
25 | Liver (cousin) | ||||||||||
112 | 169 | F | 63 | 63 (e) | — | — | — | — | — | — | — |
117 | 153 | F | 55 | 56 (c) | — | — | — | Breast (mother) | — | — | — |
109 | 27 | M | 67 | — | — | Brother (a) | — | 67 | M | 45 | |
66 | F | 40 | Daughter | ||||||||
114 | 73 | F | 22 | — | Mother (48) | Mother (51,61) (e) | — | 41 | M | 14 | |
118 | 47 | M | 23 | — | Mother (43) | Mother (51) (b) | — | — | — | — | |
101 | 154 | M | 32 | BCC (37) | Mother (65) | Mother (68) (f) | — | 185 | F | 45 | |
119 | — | — | — | — | Aunt | Sister (d) | Breast (sister, mother) | 12 | M | 53 | |
102 | 109 | M | 67 | — | — | Grandson (24) (e) | — | 133 | F | 45 | |
103 | 6 | M | 40 | — | — | Mother (71) (a) | Colon (mother) BCC/SCC Larynx (father) Liver (grand-mother) | — | — | — | |
104 | 13 | F | 67 | Colon | — | Brother (a) | Colon (brother) | — | — | — | |
106 | 160 | M | 74 | — | — | Father (68) (x) | — | 166 | M | 75 | |
108 | 131 | M | 67 | — | — | Brother (57) (x) | — | — | — | — | |
111 | 113 | F | 66 | — | — | Mother (x) | — | — | — | — | |
115 | 137 | F | 24 | — | — | Grand-mother (86) (x) | — | — | — | — | |
123 | 222 | F | 56 | — | — | Father (84) (x) | Colon (mother) | — | — | — | |
124 | 223 | M | 36 | — | — | Cousin (30) (x) | Renal (father) Gastric (aunt) | — | — | — | |
107 | 83 | F | 43 | — | — | Daughter (10) (h) | — | — | — | — | |
121 | 220 | F | 37 | — | — | Grand-father (x) | Breast (mother) | — | — | — | |
