Table 1 Cytotoxic activity of doxorubicin towards HL60 cell line and its multidrug resistant sublines: HL60/VINC and HL60/DOX

From: The role of bioreductive activation of doxorubicin in cytotoxic activity against leukaemia HL60-sensitive cell line and its multidrug-resistant sublines

 

IC50 (n M)

Cell line

Doxorubicin nonactivated

Doxorubicin activated

HL60

18.6±8.9

9.3±4.2

HL60/VINC

438±133

256±68a

HL60/DOX

1644±408

571±197b

  1. IC50 is the doxorubicin (DOX) concentration required to inhibit 50% of cell growth. The values represent mean±s.d. of five independent experiments. The significance level of the differences observed (Students's t-test).
  2. aP<0.05;
  3. bP<0.0001 vs values found for DOX alone (nonactivated).
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