Table 3 Univariate and multivariate Cox's analyses of the proposed prognostic index and the AJCC stage IV classification in patients with metastatic melanoma

From: Elevated neutrophil and monocyte counts in peripheral blood are associated with poor survival in patients with metastatic melanoma: a prognostic model

   

Univariate analyses

Multivariate analysis a

Combination of risk factors

Categories compared

Number of patients

Hazard ratio

95% CI

P -value

Hazard ratio

95% CI

P -value

LDH, neutrophils and performance status

Low vs intermediate vs high

139

  

<0.001*

  

<0.001*

 

Low vs intermediate

161

2.4

1.9–3.0

<0.001

2.2

1.7–2.9

<0.001

 

Low vs high

21

5.9

3.7–9.6

<0.001

5.4

3.3–9.0

<0.001

AJCC stage IV classification

M1a vs M1b vs M1c

56

  

<0.001*

  

0.26*

 

M1a vs M1b

48

1.4

0.9–2.1

0.11

1.3

0.9–2.0

0.21

 

M1a vs M1c

217

2.0

1.5–2.8

<0.001

1.3

0.9–1.8

0.11

  1. CI=confidence interval; LDH=lactate dehydrogenase; AJCC=American Joint Committee on Cancer; M1a=skin and lymph node involvement with normal serum LDH; M1b=including lung metastases with normal serum LDH; M1c=other visceral metastases or an elevated serum LDH. Low risk denotes a normal LDH, and a normal neutrophil count, and a performance status of 0–1. Intermediate risk denotes any combination of at least one but not all variables elevated. High risk denotes an elevated LDH, an elevated neutrophil count, and a performance status of 2.
  2. *P-values are overall estimates for all levels.
  3. aN=321, 302 deaths.
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