Table 1 Clinicopathological characteristics of first breast cancer for women who opted for CPM and women under surveillancea

From: Risk reduction of contralateral breast cancer and survival after contralateral prophylactic mastectomy in BRCA1 or BRCA2 mutation carriers

Characteristic

CPM group ( N =79)

Surveillance group ( N =69)

P -value

Age at first breast cancer (years)

 Mean±s.e.

38.0±0.9

39.4±1.0

0.295

 Range

26–56

25–64

 

Year of diagnosis

 Mean

1995

1991

<0.001

 Median

1997

1993

 

 Range

1982–2002

1972–2002

 

Breast cancer stage

 Stage I

32 (40.5)

25 (36.2)

0.324

 Stage IIa

31 (39.2)

27 (39.1)

 

 Stage IIb

10 (12.7)

15 (21.7)

 

 Stage IIIa

6 (7.6)

2 (2.9)

 

Pathological T stage (cm)

 T1: 2

43 (54.4)

38 (55.1)

0.677

 T2: 2–5

33 (41.8)

30 (43.5)

 

 T3: >5

3 (3.8)

1 (1.4)

 

Axillary status

 Node negative

52 (65.8)

40 (58.0)

0.495

 Node positive

27 (34.2)

29 (42.0)

 

Bloom & Richardson grade

 Grade I

— (0.0)

1 (2.1)

0.481

 Grade II

22 (32.4)

16 (33.3)

 

 Grade III

46 (67.6)

31 (64.6)

 

Morphology

 Ductal

68 (89.5)

49 (75.4)

0.042

 Other

8 (11.5)

16 (24.6)

 

Estrogen receptor status

 Positive

15 (26.3)

17 (44.7)

0.078

 Negative

42 (73.7)

21 (55.3)

 

Progesterone receptor status

 Positive

12 (22.6)

12 (33.3)

0.332

 Negative

41 (77.4)

24 (66.7)

 

Therapy

 Breast-conserving surgery

21 (26.6)

41 (59.4)

<0.001

 Radiotherapy

46 (58.2)

58 (84.1)

0.001

 Chemotherapy

46 (58.2)

26 (37.7)

0.014

 Hormonal therapy

15 (19.0)

4 (5.8)

0.025

  1. CPM=contralateral prophylactic mastectomy; s.e.=standard error of the mean.
  2. Values represent N (%), unless stated otherwise.