Table 3a Outcome after first breast cancer in all patients in the CPM and surveillance group

From: Risk reduction of contralateral breast cancer and survival after contralateral prophylactic mastectomy in BRCA1 or BRCA2 mutation carriers

Outcome

CPM group ( N =79)

Surveillance group ( N =69)

P -value

Follow up after first breast cancer mean±s.e. (years)

7.4±0.5

10.5±0.7

0.035

Contralateral breast cancer

N (%)

1a (1.3)

32 (46.4)

<0.001

 Time until occurrence (years)

5.4

6.4±0.8

 

Vital status, N (%)

 Alive, disease free

73 (92.4)

50 (72.5)

 

 Alive, breast cancer

1 (1.3)

7 (10.1)

 

 Alive, ovarian cancer

2 (2.5)

1 (1.4)

 

 Deceased from breast cancer

3 (3.8)

8 (11.6)

 

 Deceased from ovarian cancer

— (0.0)

2 (2.9)

 

 Deceased from other cancer

— (0.0)

1 (1.4)

 

Recurrence, N (%)

 Local recurrence

8 (10.1)

12 (17.4)

0.233

 Regional recurrence

1 (1.3)

1 (1.4)

1.000

 Distant metastasis

5 (6.3)

9 (13.0)

0.260

Interval between primary breast carcinoma and start of follow-up (Tables 3b and c)

4.0±0.5

6.8±0.7

0.001

  1. CPM=contralateral prophylactic mastectomy; s.e.=standard error of the mean.
  2. aThree ductal carcinoma in situ and one invasive breast cancers found after histological examination in the CPM were excluded.