Table 4 Risk of contralateral breast cancer and overall survival of women under surveillance compared to women who opted for CPM

From: Risk reduction of contralateral breast cancer and survival after contralateral prophylactic mastectomy in BRCA1 or BRCA2 mutation carriers

 

Univariate

Multivariate

 

HR

95% CI

P -value

HR a

95% CI

P -value

Risk of contralateral breast cancer b

 CPM vs surveillance

0.09

0.01–0.78

0.03

   

Overall mortality c

CPM versus surveillance

0.26

0.07–0.94

0.04

0.35d

0.09–1.39

0.14

  1. CPM=contralateral prophylactic mastectomy; s.e.=standard error of the mean; HR=hazard ratio; CI=confidence interval.
  2. aHR derived from Cox's proportional-hazards analysis. Confounders (see Statistical analysis) were included if they changed the HR estimate by more than 10%.
  3. bN=118 patients.
  4. cN=148 patients.
  5. dAdjusted for BPO, time between first breast cancer and the start of follow-up, and chemotherapy.
Back to article page