Table 1 Evaluation of selected serum chemistries 5 days after intratumoral injection of AdCA-mIFN

From: Adenovirus-mediated interferon α gene transfer induces regional direct cytotoxicity and possible systemic immunity against pancreatic cancer

 

AdCA-mIFN

AdCA-AP

No treatment

Dose (PFU): × 10 8

2.5

1.0

0.25

2.5

—

Mouse IFN concentration

 Tumour (pg g−1): × 103

252.3±292.2

53.0±30.0

14.3±13.4

1.4±0.6

0.8±0.2

 Serum (pg ml−1): × 103

1.7±0.9

0.3±0.1

0.3±0.2

0.2±0.1

0.2±0.1

 Albumin (g dl−1)

2.8±0.3

2.9±0.4

2.8±0.4

2.7±0.1

2.9±0.3

 Alk. phos. (IU l−1)

231±71

186±29

199±44

186±21

218±81

 Amylase (U l−1)

13 910±3932

16 595±6937

17 790±453

14 850±353

10 269±3922

 BUN (mg dl−1)

19.1±1.6

23.6±6.4

21.2±2.4

22.7±1.3

23.9±4.0

 Creatinine (mg dl−1)

0.08± 0.02

0.09± 0.02

0.1±0.01

0.09±0.02

0.11±0.03

 LDH (IU l−1)

379± 69

316±68

560±244

486±252

368±216

 AST (IU l−1)

126±4

101±42

93±34

68±17

70±23

 ALT (IU l−1)

54±32

28±4

25±7

18±10

19±5

 T. bil. (mg dl−1)

0.05±0.01

0.04±0.01

0.05±0.01

0.06±0.01

0.04±0.01

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