Figure 1 | British Journal of Cancer

Figure 1

From: Angiotensin II directly induces muscle protein catabolism through the ubiquitin–proteasome proteolytic pathway and may play a role in cancer cachexia

Figure 1

(A) Effect of Ang I on total protein degradation in murine myotubes in the absence (♦) or presence of imidaprilat (50 μ M) (▴) or EPA (50 μ M) (□). (B) Effect of Ang II on total protein degradation in murine myotubes after 24 h incubation in the absence (♦) or presence (□) of 50 μ M EPA. (C) Effect of Ang I and (D) effect of Ang II on total protein degradation in the absence (♦) or presence of lactacystin (5 μ M) (▴) or MG132 (10 μ M) (□). Differences from control in the presence of Ang I and Ang II are indicated as c, P<0.001, while differences in the presence of the inhibitors are indicated as e, P<0.01 or f, P<0.001. n=6.

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