Table 2 Tumour characteristics at the time of diagnosis according to cyclin A positivity
From: Cyclin A as a marker for prognosis and chemotherapy response in advanced breast cancer
Cyclin A<10.5% | Cyclin A>10.5% | ||
|---|---|---|---|
Tumour characteristic | No. of patients (%) | No. of patients (%) | P -value |
Tumour size | |||
0–2 cm | 10 (30) | 14 (22) | |
2.1–5 cm | 12 (36) | 29 (46) | |
>5 cm | 4 (12) | 9 (14) | |
Direct extension to skin or chest wall | 2 (6) | 4 (6) | NS |
Unknown | 5 (15) | 7 (11) | |
Nodal status | |||
Negative | 12 (36) | 19 (30) | |
Positive | 18 (55) | 36 (57) | |
Fixed lymph nodes | 2 (6) | 7 (11) | |
Unknown | 1 (3) | 1 (2) | NS |
Primary metastatic disease | |||
No | 23 (70) | 51 (81) | |
Yes | 6 (18) | 7 (11) | |
Unknown | 4 (12) | 5 (8) | NS |
Hormone receptor status | |||
ER+ | 10 (30) | 29 (46) | |
ER− | 21 (64) | 27 (43) | |
Unknown | 2 (6) | 7 (11) | P=0.003 |
Histology | |||
Ductal | 31 (94) | 63 (100) | |
Lobular | 2 (6) | ||
c-erb-B2 | |||
Low | 5 (15) | 29 (46) | |
Intermediate | 3 (9) | 16 (25) | |
High | 11 (33) | 18 (28) | NS |
Grade | |||
1 | 3 (9) | 1 (2) | |
2 | 17 (52) | 13 (21) | |
3 | 13 (39) | 49 (78) | P<0.001 |
