Table 2 Statistics of IIRK and IhERG in controls and glioma cases

From: hERG1 channels are overexpressed in glioblastoma multiforme and modulate VEGF secretion in glioblastoma cell lines

Grade

N cases ( N cells)

Average current expression (%)

Current density (pA pF−1)

I IRK

   

 Controls

4 (42)

30±11

−22.0±4.4 (11)

 AI–III

3 (31)

22±14

−11.3±3.7 (6)

 GBM

12 (153)

28±4

−12.4±1.7 (40)*

 OD/OA

2 (16)

29

−4.4±0.7 (4)*

I hERG

   

 Controls

0

NA

NA

 AI–III

1 (6)

17

ND

 GBM

11 (108)

35±8

−7.84±1 (24)

 OD/OA

0

NA

NA

I hELK2

   

 Controls

0

NA

NA

 AI–III

1 (4)

25

ND

 GBM

3 (45)

22±3

−17.4±6 (9)

 OD/OA

0

NA

NA

  1. N cases=number of cases in which the indicated K+ current was detected; average current expression=the fraction of cells showing the indicated current was calculated for each case and the results thus obtained were averaged; current density=average current density at −100 mV; ND=not determined; NA=not applicable. Cell count is reported in parentheses. *Significantly different from the controls (0.01<P<0.05).
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