Table 3 NCI-CTC grade 1–4 nonhaematological and haematological toxicities by dose levels (all cycles)

From: A phase I pharmacokinetic and pharmacodynamic study of BGC9331 and carboplatin in relapsed gynaecological malignancies

 

Dose level

 

1

2

3

4

Grade 1 and 2 toxicities

 Lethargy

3/3

1/3

2/6

2/2

 Vomiting

1/3

1/3

0/6

0/2

 Nausea

2/3

3/3

2/6

2/2

 Diarrhoea

0/3

0/3

2/6

0/2

 Alopecia

1/3

2/3

2/6

1/2

 Rash

0/3

0/3

2/6

1/2

 Peripheral neuropathy

1/3

0/3

2/6

0/2

 Mucositis

0/3

1/3

0/6

1/2

 Anaemia

2/3

2/3

2/6

0/2

 Thrombocytopaenia

0/3

1/3

1/6

2/2

 Neutropaenia

1/3

1/3

2/6

2/2

Grade 3 and 4 toxicities

 Lethargy

0/3

0/3

2/6

1/2

 Nausea

0/3

0/3

1/6

1/2

 Diarrhoea

0/3

0/3

0/6

1/2

 Thrombocytopaenia

0/3

0/3

0/6

0/2

 Neutropaenia

0/3

1/3

1/6

1/2

Back to article page