Table 3 Pathological response

From: A phase I/II study of oxaliplatin when added to 5-fluorouracil and leucovorin and pelvic radiation in locally advanced rectal cancer: a Colorectal Clinical Oncology Group (CCOG) study

Oxaliplatin dose (mg m−2)

85

130

150

All (%)

Number of patients

6

20

6

32

Number operated

6

19a

3b

28

pCR

0/6

2/19

0/2

2/27 (7%)

pT0–2 pN0

2/6

6/19

0/2

8/27 (30%)

Tmic

1/6

2/19

0/2

3/27 (11%)

−ve CRMc

5/6

15/19

2/2

22/27 (81%)

  1. aOne patient inoperable.
  2. bOne inoperable, one unfit for surgery, one patient refused, one specimen lost.
  3. c−ve CRM=tumour clearance of more than 1 mm from circumferential resection margin, pCR=histopathological complete response; Tmic=microscopic disease only detected in surgical specimen; CRM=circumferential resection margin.
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