Table 1 Cohort studies on in vitro fertilization and childhood cancer

From: Meta-analysis of cancer incidence in children born after assisted reproductive technologies

Authors (year)

Country

Number of exposed children

Follow-up

Cancer results

White et al (1990)

Australia

2285a

Absent

Three neuroectodermal tumours

Rufat et al (1994)

France

1637

Minimum follow-up: 1 year

One leukaemia

Doyle et al (1998)

Britain

2507

Average follow-up: 8.6 years

Two unspecified cancers

Bergh et al (1999)

Sweden

5586

Maximum follow-up: 13 years

One ALL, one reticulosis, one upper extremities, one peripheral nerves cancer

Bruinsma et al (2000)

Australia

5249

Average follow-up: 3 years, 9 months

One brain, one connective tissue, three leukaemia, one salivary gland cancer

Lerner-Geva et al (2000)

Israel

332

710 person years

0 cancers

Klip et al (2001)

Netherlands

9479 (429 after hormonal treatment)

Average follow-up: 4.6 years

Three leukemia, four unspecified cancers

Ericson et al (2002)

Sweden

9056

Maximum follow-up: 13 years

Three ALL, two histiocytosis, two sarcomas, two CNS, one retinal, one hepatic carcinoma

Odone-Filho et al (2002)

Brazil

b

Maximum follow-up: 5 years

One AML, one neuroblastoma, two rhabdo myosarcoma

Moll et al (2003)

Netherlands

c

Maximum follow-up: 1 year, 2 months

Five retinoblastoma

Pinborg et al (2003)

Denmark

1080 (454 twins)

Maximum follow-up: 4 years

One 1 ALL, one germinal cell tumour

Pinborg et al (2004a)

Denmark

3393 (twins)

Minimum follow-up: 1 year

0 cancers

Pinborg et al (2004b)

Denmark

8523 (3393 twins)

Minimum follow-up: 1 year

ALL, hepatoblastoma, unspecific tumours of thorax, heart, cerebrum

Bradbury and Jick (2004)

USA

176

Maximum follow-up: 13 years

0 cancers

  1. aCohort without a systematic follow-up.
  2. bHypothetical cohort, assuming that approximately 2000 children were conceived after IVF during the period 1996–2000.
  3. cHypothetical cohort, assuming that 1–1.5% of children were conceived after IVF.
  4. ALL=acute lymphoblastic leukaemia; CNS=central nervous system; AML=acute myelocytic leukaemia.