Table 2 Cohort studies included in the meta-analysis

From: Meta-analysis of cancer incidence in children born after assisted reproductive technologies

Author (year)

Number of exposed children

Calculation of expected cases (EC)

Observed/expected cases ( N)

Standardized incidence ratio (95%CI)

White et al (1990)

2285

No calculation in the original study. EC calculated by applying cancer incidence rates from the original study to the IVF cohort

3/0.13

23.08 (8.38–67.31)

Rufat et al (1994)

1637

No calculation in the original study. EC calculated by applying published cancer incidence rates (Bernard et al, 1993; Gembara et al, 1995) to the IVF cohort

1/0.7

1.43 (0.31–3.79)

Doyle et al (1998)

2507

Application of cumulative national cancer rates, taking into account year of birth and length of follow-up

2/3.5

0.57 (0.07–2.06)

Bruinsma et al (2000)

5249

Application of the Victorian cancer incidence rates, taking into account age and length of follow-up

6/4.33

1.39 (0.62–3.09)

Lerner-Geva et al (2000)

332

Application of specific national cancer incidence rates, taking into account age, gender and year of diagnosis

0/1.7

0 (0–2.18)a

Klip et al (2001)

9050b

Application of cancer incidence rates from the Eindhoven and the Netherlands Cancer Registries, taking into account age, gender and calendar period

6/6.78

0.88 (0.41–1.98)

Ericson et al (2002)

9056

Application of the Swedish Cancer Registry cancer incidence rates, taking into account year of birth, maternal age, parity and length of involuntary childlessness

11/12.5

0.88 (0.5–1.13)

Odone-Filho et al (2002)

Around 2000

Application of annual incidence rate of cancer for children aged 0–4 years

4/1.17

3.42 (1.42–8.76)

Moll et al (2003)

Not known

Application of the 1-year age-specific mortality rates from statistics in the Netherlands

5/0.69

7.25 (3.19–17.03)

Pinborg et al (2004a, 2004b)

8523

No calculation in the original study. EC calculated by applying the 0–6 years cancer incidence rates from the Danish Cancer Registry to the IVF cohort

9/6.7

1.34 (0.71–1.78)

Bradbury and Jick (2004)

176

No calculation in the original study. EC were calculated by applying retinoblastoma incidence rates from the original study to the IVF cohort

0/0.01

0 (0–7.40)a

  1. aThe upper confidence limit was calculated using 0.5 as observed number of cases.
  2. bIn all, 429 children conceived after hormonal treatment, but not after ART, were excluded.
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