Table 2 Toxicities (Grade 3/4)

From: Combination chemotherapy with carboplatin, capecitabine and epirubicin (ECarboX) as second- or third-line treatment in patients with relapsed ovarian cancer: a phase I/II trial

Dose level

1

2

3

−1

−2

Summary

Capecitabine (mg m−2 BD)

375 q21

500 q21

625 q14

500 q14

375 q14

 

Patient number

n=3

n=5

n=1

n=6

n=3

n=18

Neutropenia grade

2

2

1

3

1

9

Thrombocytopenia grade

   

1

 

1

Stomatitis grade

    

1

1

Diarrhoea

1

    

1

Fatigue

 

1

   

1

PPS

   

1

 

1

Median delay (weeks) (range)

3 (0–4)

2 (1–4)

2

1 (0–2)

3 (1–5)

2 (0–5)

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