Table 1 Model parameter estimates

From: Mechanistic mathematical modelling of mercaptopurine effects on cell cycle of human acute lymphoblastic leukaemia cells

 

P12

Molt-4 sensitive

Molt-4 resistant

Parameter

Control

Treated

Control

Treated

Control

Treated

α S

0.1559 (4.8)a

 

0.1588 (4.0)a

 

0.1182 (3.8)a

 

α M

0.0941 (3.3)a

 

0.1388 (3.7)a

 

0.1238 (4.1)a

 

CCTb

20.0

 

15.0

 

18.0

70.8

γ 1

0.0184 (11.6)a

NSC*

0.0503 (5.5)a

0.1210 (10.0)a

0.0152 (15.6)a

NSC*

γ 2

0.1438 (18.2)a

NSC*

0.4118 (11.8)

0.0829 (6.1)

0.0956 (25.5)a

0.1555 (9.2)a

γ 3

0.1064 (23.3)a

NSC*

0.2915 (11.3)

0.0485 (8.7)a

0.07329 (37.3)a

0.1045 (10.7)a

f

 

0.7277 (3.4)a

 

0.5080 (7.7)a

 

1.0

α SI

 

NSC*

 

NSC*

 

0.2289 (10.1)a

α MI

 

0

 

0

 

0.0154 (15.3)a

γ MP

 

0.0671 (6.9)a

 

0.0758 (9.0)a

 

0.0402 (7.5)a

  1. aCoefficient of variation (%).
  2. bCell cycle time (h).
  3. *No significant change.
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