Table 3 Haematological (grade 3–4) and nonhaematological (grade 2–4) toxicities (worst grade over cycles of docetaxel-based chemotherapy received)

From: SCOTROC 2A: Carboplatin followed by docetaxel or docetaxel–gemcitabine as first-line chemotherapy for ovarian cancer

  

Docetaxel alone (arm A)

Docetaxel–gemcitabine (3-weekly) (arm B)

Docetaxel–gemcitabine (weekly) (arm C)

Toxicity

Grade

%

Count

%

Count

%

Count

Haematological

 Neutropenia

3

11.1

4

38.1

16

22.9

8

 

4

66.7

24

47.6

20

28.6

10

 White blood cells

3

40.5

15

40.5

17

42.9

15

 

4

24.3

9

7.1

3

5.7

2

 Platelets

3

8.1

3

4.8

2

11.4

4

 

4

0.0

0

4.8

2

0.0

0

 Haemoglobin

3

0.0

0

9.5

4

8.6

3

 

4

0.0

0

2.4

1

2.9

1

Nonhaematological

 Alopecia

2

73.0

27

64.3

27

19.8

7

 Nausea

2

13.5

5

9.5

4

28.6

10

 

3

0.0

0

7.1

3

2.9

1

 Vomiting

2

8.1

3

2.4

1

11.4

4

 

3

0.0

0

4.8

2

2.9

1

 Sensory neuropathy

2

13.5

5

4.8

2

5.7

2

 

3

2.7

1

0.0

0

0.0

0

 Motor neuropathy

2

2.7

1

0.0

0

0.0

0

 

3

0.0

0

2.4

1

2.9

1

 Diarrhoea

2

16.2

6

11.9

5

14.3

5

 

3

2.7

1

7.1

3

0.0

0

 Constipation

2

16.2

6

9.5

4

11.4

4

 

3

0.0

0

2.4

1

5.7

1

 Stomatitis

2

29.7

11

21.4

9

2.9

1

 

3

5.4

2

0

0

0.0

0

 Shortness of breath

2

10.8

4

35.7

15

40.0

14

 

3

0.0

0

4.8

2

5.7

2

 

4

0.0

0

0.0

0

2.9

1

 Abdominal pain or cramping

2

10.8

4

4.8

2

8.6

3

 

3

0.0

0

2.4

1

5.7

2

 

4

0.0

0

2.4

1

0.0

0

 Fatigue (lethargy, malaise, asthenia)

2

43.2

16

48.6

18

51.4

18

 

3

5.4

2

2.7

1

17.1

6

Back to article page