Table 3 Immune cell infiltration into HER2-overexpressing breast tumours following PST

From: Trastuzumab-based treatment of HER2-positive breast cancer: an antibody-dependent cellular cytotoxicity mechanism?

 

TAXHER01 ( n =23)

HER2 control ( n =15)

TAXHER01 vs control

Antibodies location

Mean (s.d.) staining intensity score

P -value

CD20

 Diffuse

1.61 (1.27)

1.53 (1.19)

0.8525

 Around

1.13 (1.52)

0.40 (1.06)

0.1036

 Inside

0.43 (0.94)

0.20 (0.77)

0.2488

 Foci

3.13 (1.18)

2.13 (1.64)

0.0840

CD3

 Diffuse

2.09 (1.41)

1.80 (1.08)

0.3734

 Around

1.52 (1.62)

0.93 (1.44)

0.2352

 Inside

0.65 (1.19)

0.40 (0.74)

0.6948

 Foci

2.87 (1.06)

1.67 (1.40)

0.0046

CD4

 Diffuse

1.04 (1.33)

0.87 (0.91)

0.9618

 Around

1.35 (1.67)

0.33 (0.72)

0.0605

 Inside

0.35 (0.71)

0.00 (0.00)

0.0565

 Foci

2.17 (1.27)

1.53 (1.30)

0.1423

CD8

 Diffuse

1.96 (1.49)

2.00 (1.00)

0.9259

 Around

1.56 (1.70)

0.80 (1.21)

0.1342

 Inside

1.22 (1.31)

0.67 (0.90)

0.2039

 Foci

2.39 (1.62)

2.33 (1.17)

0.5882

CD68

 Diffuse

1.91 (1.31)

3.13 (0.74)

0.0037

 Around

0.91 (1.59)

0.00 (0.00)

0.0341

 Inside

0.56 (0.99)

0.33 (0.72)

0.5592

 Foci

0.09 (0.42)

0.00 (0.00)

0.4193

PS100

 Diffuse

1.70 (1.29)

2.00 (1.07)

0.4600

 Around

1.35 (1.64)

0.67 (1.29)

0.2253

 Inside

0.61 (1.31)

0.20 (1.56)

0.4394

 Foci

1.74 (1.66)

1.27 (1.53)

0.3246

CD1a

 Diffuse

1.61 (0.78)

1.80 (0.77)

0.4990

 Around

0.39 (0.72)

0.40 (0.91)

0.7634

 Inside

0.26 (0.54)

0.27 (0.80)

0.5800

 Foci

0.00 (0.00)

0.00 (0.00)

 

HLA-DR

 Diffuse

2.09 (1.04)

2.40 (0.91)

0.5216

 Around

1.69 (1.72)

0.73 (1.33)

0.0786

 Inside

0.91 (1.16)

0.53 (0.92)

0.3676

 Foci

2.30 (1.15)

2.00 (1.20)

0.5809

CD56 a

 Diffuse

0.83 (1.03)

0.67 (0.82)

0.7562

 Around

1.00 (1.51)

0.80 (1.08)

0.8762

 Inside

0.30 (0.70)

0.20 (0.56)

0.7062

 Foci

0.26 (0.69)

0.53 (1.12)

0.4797

NK1

 Diffuse

1.45 (1.40)

1.20 (0.86)

0.5737

 Around

1.64 (1.56)

0.40 (1.12)

0.0097

 Inside

0.82 (1.26)

0.20 (0.77)

0.0532

 Foci

2.05 (1.43)

1.07 (1.16)

0.0303

TiA1

 Diffuse

1.13 (1.32)

1.67 (0.82)

0.1448

 Around

1.43 (1.73)

0.53 (1.41)

0.0942

 Inside

0.65 (1.03)

0.07 (0.26)

0.0407

 Foci

1.00 (1.20)

1.00 (1.51)

0.8120

Granzyme B

 Diffuse

0.26 (0.69)

0.33 (0.49)

0.3126

 Around

0.82 (1.33)

0.27 (0.80)

0.1374

 Inside

0.22 (0.67)

0.07 (0.26)

0.5188

 Foci

0.52 (0.85)

0.27 (0.80)

0.1758

  1. NT–NT, anthracycline-based PST that does not include a taxane or trastuzumab; D, docetaxel-based PST.
  2. For diffuse/around/inside/foci, scores range from 0 to 4.
  3. aStaining with CD56 was less intense and difficult to quantify. Significant if P<0.05. Bold values signify their importance in the results and the discussion.
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