Table 3 Overall spatial heterogeneity in the incidence of childhood acute leukaemia in France using Rogerson's statistic (1999)

From: Spatial and space–time clustering of childhood acute leukaemia in France from 1990 to 2000: a nationwide study

 

Whole period 1990–2000

1990–1994

1995–2000

 

No. cases

R H0 a

RObsa (pb)

No. cases

R H0

R Obs (p)

No. cases

R H0

R Obs (p)

Age at diagnosis – d=40 km

0–14 years

4873

0.74

0.90 (0.09)

2226

1.61

2.04 (0.06)

2647

1.36

1.36 (0.31)

0–4 years

2458

1.46

1.60 (0.25)

1136

3.16

4.05 (0.04)

1322

2.71

2.54 (0.63)

5–9 years

1427

2.51

2.21 (0.79)

662

5.42

4.94 (0.71)

765

4.69

4.50 (0.56)

10–14 years

988

3.63

4.14 (0.19)

428

8.39

9.54 (0.20)

560

6.41

6.67 (0.36)

Spatial limit of proximity d – Analyses in the 0–4 year age group

20 km

2458

1.47

1.65 (0.10)

1136

3.49

3.56 (0.12)

1322

2.74

2.58 (0.74)

30 km

2458

1.47

1.67 (0.12)

1136

3.17

3.86 (0.05)

1322

2.72

2.59 (0.65)

40 km

2458

1.46

1.60 (0.25)

1136

3.16

4.05 (0.04)

1322

2.71

2.54 (0.63)

50 km

2458

1.45

1.56 (0.32)

1136

3.14

4.05 (0.05)

1322

2.70

2.44 (0.70)

  1. aRH0 and RObs refer to the value of the statistic expected under the null hypothesis of nonspatial heterogeneity and the observed value, respectively.
  2. bThe statistical thresholds were evaluated as the one-sided tail probability of the distribution expected under the null hypothesis (999 Monte Carlo simulations).
  3. Bold highlights the main results, those associated to a P-value <5%.