Table 4 Space–time interaction between the dates and places of diagnosis of childhood acute leukaemia in France 1990–2000 (Knox, 1964)

From: Spatial and space–time clustering of childhood acute leukaemia in France from 1990 to 2000: a nationwide study

  

Time t (months)

Age (y)

Distance d (km)

1

3

6

9

12

0–14

0

0.94 (764)

0.95 (1804)

0.99 (3442)

0.99 (4970)

1.00 (6502)

 

5

0.98 (1458)

0.98 (3398)

1.00 (6330)

1.00 (9116)

1.00 (11884)

 

10

1.00 (4082)

0.99 (9448)

1.00 (17386)

1.00 (25260)

1.00 (32768)

 

15

1.01 (7252)

0.99 (16596)

1.00 (30604)

1.00 (44414)

1.00 (57826)

 

20

1.01 (10632)

1.00 (24456)

1.00 (44850)

1.01 (65066)

1.01 (84752)

 

30

1.01 (16568)

1.00 (38124)

1.00 (69784)

1.00 (101274)

1.01 (132026)

 

50

1.00 (25302)

1.00 (58470)

1.00 (107350)

1.00 (155570)

1.00 (202860)

0–4

0

1.04 (284)

0.93 (588)

1.00 (1162)

1.00 (1680)

1.00 (2196)

 

5

1.04 (476)

1.00 (1052)

1.04 (2012)

1.01 (2828)

1.01 (3680)

 

10

1.03 (1238)

1.02 (2814)

1.02 (5174)

1.01 (7410)

1.00 (9604)

 

15

1.04 (2144)

1.02 (4860)

1.02 (8950)

1.01 (12774)

1.01 (16632)

 

20

1.02 (2954)

1.02 (6866)

1.02 (12572)

1.02 (18190)

1.02 (23682)

 

30

1.02 (4520)

1.02 (10418)*

1.01 (18972)

1.01 (27458)

1.01 (35832)

 

50

1.00 (6698)

1.00 (15496)

1.00 (28506)

1.00 (41236)

1.01 (53866)

5–9

0

0.81 (46)

0.95 (124)

1.00 (238)

0.95 (328)

1.00 (444)

 

5

0.95 (102)

1.00 (248)

0.99 (450)

0.97 (634)

0.98 (828)

 

10

0.99 (304)

0.97 (690)

0.98 (1266)

0.98 (1830)

0.98 (2372)

 

15

1.01 (542)

1.03 (1280)

0.99 (2256)

1.00 (3288)

1.02 (4316)

 

20

1.01 (820)

1.03 (1928)

0.97 (3332)

0.99 (4862)

1.00 (6410)

 

30

0.99 (1282)

1.02 (3050)

0.98 (5342)

0.99 (7784)

1.00 (10222)

 

50

0.98 (2040)

1.01 (4882)

0.99 (8720)

1.00 (12734)

1.01 (16562)

10–14

0

1.00 (20)

1.13 (52)

1.32 (112)*

1.20 (148)

1.15 (184)

 

5

0.85 (42)

1.03 (118)

1.15 (242)

1.12 (342)

1.09 (432)

 

10

0.86 (126)

0.92 (312)

0.96 (600)

0.98 (886)

1.00 (1168)

 

15

0.92 (250)

0.97 (608)

1.05 (1210)

1.05 (1746)

1.01 (2190)

 

20

0.96 (392)

0.98 (924)

1.00 (1734)

1.00 (2520)

0.99 (3226)

 

30

0.99 (648)

0.99 (1490)

0.99 (2750)

0.99 (3990)

0.99 (5162)

 

50

0.97 (982)

1.00 (2344)

1.00 (4288)

1.00 (6222)

1.00 (8084)

  1. * P<0.05.
  2. These figures refer to O/E (O).
  3. O is the observed number of close pairs of cases (up to d kilometres and t months apart) among n(n−1)/2 possible pairs, n being the total number of cases in the period and age group under consideration.
  4. E is the number of close pairs expected under the hypothesis of no interaction. The statistical thresholds were evaluated as the one-sided tail probability of the distribution of O under the null hypothesis (499 Monte Carlo simulations).
  5. Bold highlights the main results, those associated to a P-value <5%.
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