Table 2 Summary of D-Loop somatic mutations found in the 109 HNSCC patients
From: Clinicopathological significance of mitochondrial D-Loop mutations in head and neck carcinoma
Patients number | Nucleotide position | DNA (N → T) a | MtDNA mutation status |
|---|---|---|---|
16 | 303–309 | C7 → C7/C9 | Heteroplasmy |
22 | 214 | A → G | Homoplasmy |
303–309 | C8/C9 → C8 | Homoplasmy | |
23 | 514 | (CA)5 → (CA)4 | Homoplasmy |
28 | 314 | C → T | Homoplasmy |
32 | 303–309 | C8 → C7 | Homoplasmy |
42 | 303–309 | C7 → C7/C9 | Heteroplasmy |
43 | 303–309 | C8/C9 → C8/C10 | Heteroplasmy |
48 | 303–309 | C8 → C7/C8 | Heteroplasmy |
53 | 303–309 | C8 → C8/C9 | Heteroplasmy |
63 | 303–309 | C8/C9 → C8 | Homoplasmy |
82 | 303–309 | C9/C10 → C9 | Homoplasmy |
110 | 303–309 | C7 → C6/C7 | Heteroplasmy |
114 | 303–309 | C8/C9 → C9/C10 | Heteroplasmy |
118 | 213 | A → G | Homoplasmy |
127 | 303–309 | C8 → C8/C9 | Heteroplasmy |
141 | 303–309 | C9 → C8 | Homoplasmy |
146 | 408 | T → A | Heteroplasmy |
153 | 239 | C → T | Homoplasmy |
303–309 | C7 → C9/C10 | Heteroplasmy | |
155 | 303–309 | C8/C9 → C9 | Heteroplasmy |
161 | 303–309 | C8 → C7/C8 | Heteroplasmy |
167 | 303–309 | C8/C9 → complex | Heteroplasmy |
180 | 303–309 | C9 → C8/C9 | Heteroplasmy |
206 | 303–309 | C8 → C8/C9 | Heteroplasmy |
