Figure 2
From: Radiosensitivity in breast cancer assessed by the Comet and micronucleus assays
Spontaneous MN expression (A) and the slopes (B) of the dose–response curves for MN induction after in vitro irradiation with 0–4 Gy in PBMCs derived from unselected (circles) and sensitive (unfilled down triangles) cancer patients are shown in comparison with those in the cells from control subjects (squares). Each data point in (A) represents the mean frequency of micronucleated BNCs scored in 1000 BNCs. Each data point in (B) represents the slope of the dose–response curve for MN induction in 1000 BNCs (per a single dose of radiation) from a given individual. Filled triangles represent the mean values for the respective group. ‘NS’ indicates that the difference was not highly significant (P>0.05). To facilitate visual comparison, the dashed line is drawn through the mean value of the group of healthy donors. Star and diamond represent the data for patients 016 and 021 who revealed an adverse skin reaction after RT.
