Table 1 Associations between CCND1 A870G genotype and colorectal carcinoma and adenoma risk in the NHS, HPFS, and PHS

From: Cyclin D1 A870G polymorphism and the risk of colorectal cancer and adenoma

CCND1 G to A

Cases (%)

Controls (%)

OR (95% CI)

Cancer overall

 N

610

1237

 

 GG

125 (20.5)

264 (21.3)

1.0a

 AG

311 (51)

593 (48)

1.03 (0.78–1.36)

 AA

174 (28.5)

380 (30.7)

1.12 (0.90–1.41)

 AA+AG

485 (79.5)

973 (78.7)

1.04 (0.82–1.32)

 P for trend

  

0.64

Adenoma overall

 N

896

1229

 

 GG

187 (20.9)

241 (19.6)

1.0a

 AG

441 (49.2)

614 (50)

0.95 (0.77–1.18)

 AA

268 (29.9)

374 (30.4)

1.00 (0.78–1.28)

 AA+AG

709 (79.1)

988 (80.4)

0.96 (0.79–1.18)

 P for trend

  

0.99

NHS cancer b

 N

181

475

 

 GG

29 (16)

110 (23.2)

1.0a

 AG

95 (52.5)

224 (47.2)

1.61 (0.96–2.68)

 AA

57 (31.5)

141 (29.7)

1.55 (0.90–2.69)

 AA+AG

152 (84)

365 (76.8)

1.59 (0.98–2.57)

 P for trend

  

0.16

NHS adenoma c

 N

524

517

 

 GG

108 (20.6)

100 (19.3)

1.0a

 AG

265 (50.6)

266 (51.5)

0.95 (0.67–1.33)

 AA

151 (28.8)

151 (29.2)

0.92 (0.63–1.34)

 AA+AG

416 (79.4)

417 (80.7)

0.94 (0.68–1.29)

 P for trend

  

0.66

PHS cancer c

 N

258

415

 

 GG

56 (21.7)

85 (20.5)

1.0a

 AG

136 (52.7)

203 (48.9)

1.02 (0.68–1.55)

 AA

66 (25.6)

127 (30.6)

0.80 (0.51–1.27)

 AA+AG

202 (78.3)

330 (79.5)

0.94 (0.64–1.39)

HPFS cancer b

 N

171

347

 

 GG

40 (23.4)

69 (19.9)

1.0a

 AG

80 (46.8)

166 (47.8)

0.86 (0.53–1.40)

 AA

51 (29.8)

112 (32.3)

0.81 (0.48–1.38)

 AA+AG

131 (76.6)

278 (80.1)

0.84 (0.53–1.33)

 P for trend

  

0.45

HPFS adenoma c

 N

372

712

 

 GG

79 (21.2)

141 (19.8)

1.0a

 AG

176 (47.3)

348 (48.9)

0.96 (0.68–1.36)

 AA

117 (31.5)

223 (31.3)

0.91 (0.63–1.33)

 AA+AG

293 (78.8)

571 (80.2)

0.94 (0.68–1.31)

 P for trend

  

0.61

  1. CCND1=cyclin D1; CI=confidence interval; HPFS=Health Professionals’ Follow-Up Study; NHS=Nurses’ Health Study; OR=odds ratio; PHS=Physicians’ Health Study.
  2. aReference group.
  3. bUnconditional logistic regression adjusted for age, family history of colorectal cancer, smoking history, aspirin use, BMI, PMH use, physical activity, and intake of red meat, charred meat, folate, and alcohol.
  4. cUnconditional logistic regression adjusted for age, previous endoscopy, year of endoscopy, family history of colorectal cancer, pack-years smoking, aspirin use, BMI, PMH use (NHS only), physical activity, and intake of red meat, charred meat, folate, and alcohol.
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