Table 2 Relationship between family history of colorectal cancer and risk of colorectal cancer and adenoma among postmenopausal women in the NHS and men in the HPFS, stratified by CCND1 A870G genotype

From: Cyclin D1 A870G polymorphism and the risk of colorectal cancer and adenoma

 

Family history of colorectal cancer

 
 

No

Yes

 
 

Case/control

OR (reference)

Case/control

OR (95% CI)

P for interaction

NHS cancer a *

   

0.06

 GG

22/89

1.0

7/21

1.15 (0.38–3.50)

 

 GA/AA

113/316

1.0

31/45

1.95 (1.13–3.34)

 

NHS adenoma b

   

0.77

 GG

75/76

1.0

33/24

1.77 (0.84–3.72)

 

 GA/AA

295/338

1.0

121/79

1.85 (1.31–2.61)

 

HPFS cancer a

   

0.80

 GG

27/59

1.0

13/10

3.15 (1.14–8.67)

 

 GA/AA

107/241

1.0

24/37

1.44 (0.80–2.57)

 

HPFS adenoma b

   

0.02

 GG

74/126

1.0

5/15

0.52 (0.17–1.60)

 

 GA/AA

262/543

1.0

31/28

2.28 (1.32–3.95)

 
  1. CCND1=cyclin D1; CI=confidence interval; HPFS=Health Professionals’ Follow-Up Study; NHS=Nurses’ Health Study; OR=odds ratio.
  2. *Case and control numbers differ from total because of missing information on family history.
  3. aUnconditional logistic regression adjusted for age, PMH use (NHS only), smoking history, aspirin use, BMI, physical activity, and intake of red meat, charred meat, folate, and alcohol.
  4. bUnconditional logistic regression adjusted for age, history of previous endoscopy, year of endoscopy, PMH use, aspirin use, BMI, physical activity, and intake of red meat, well-done meat, folic acid, alcohol, total calories, and caloric-adjusted total fat.
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